Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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A-375 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 1 | 1048 | 223 | 0.0449 | 0.0379 | 0.2128 | 0.2522 |
A-375 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 2 | 953 | 248 | 0.0384 | 0.0379 | 0.2602 | 0.2522 |
A-375 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 3 | 783 | 222 | 0.0305 | 0.0379 | 0.2835 | 0.2522 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 1 | 3021 | 208 | 0.1530 | 0.1526 | 0.0689 | 0.0765 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 2 | 2993 | 236 | 0.1500 | 0.1526 | 0.0789 | 0.0765 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 3 | 3098 | 253 | 0.1548 | 0.1526 | 0.0817 | 0.0765 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 1 | 2104 | 186 | 0.1043 | 0.1039 | 0.0884 | 0.0932 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 2 | 2114 | 207 | 0.1037 | 0.1039 | 0.0979 | 0.0932 |
A-375 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 3 | 2099 | 196 | 0.1035 | 0.1039 | 0.0934 | 0.0932 |
A-375 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 1 | 2057 | 251 | 0.0982 | 0.0854 | 0.1220 | 0.1306 |
A-375 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1845 | 254 | 0.0865 | 0.0854 | 0.1377 | 0.1306 |
A-375 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1515 | 200 | 0.0715 | 0.0854 | 0.1320 | 0.1306 |
A-375 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 1 | 1078 | 291 | 0.0428 | 0.0316 | 0.2699 | 0.3337 |
A-375 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 2 | 719 | 294 | 0.0231 | 0.0316 | 0.4089 | 0.3337 |
A-375 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 3 | 779 | 251 | 0.0287 | 0.0316 | 0.3222 | 0.3337 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 20360 | 1046 | 1.0111 | 1.0000 | 0.0514 | 0.0527 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 2 | 20251 | 1109 | 1.0021 | 1.0000 | 0.0548 | 0.0527 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 3 | 19884 | 1032 | 0.9869 | 1.0000 | 0.0519 | 0.0527 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 16059 | 813 | 0.7981 | 0.7489 | 0.0506 | 0.0459 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 2 | 14559 | 660 | 0.7276 | 0.7489 | 0.0453 | 0.0459 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 3 | 14373 | 599 | 0.7211 | 0.7489 | 0.0417 | 0.0459 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 9957 | 502 | 0.4950 | 0.4801 | 0.0504 | 0.0412 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 2 | 9020 | 322 | 0.4553 | 0.4801 | 0.0357 | 0.0412 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 3 | 9724 | 364 | 0.4900 | 0.4801 | 0.0374 | 0.0412 |
A-375 | Vemurafenib | Saracatinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 9132 | 411 | 0.4565 | 0.3648 | 0.0450 | 0.0413 |