Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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A-375 | Vemurafenib | Dasatinib | 0.316 | 0.000 | uM | 72 | hr | 2 | 5304 | 139 | 0.2615 | 0.2652 | 0.0262 | 0.0225 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 0.000 | uM | 72 | hr | 3 | 5737 | 112 | 0.2848 | 0.2652 | 0.0195 | 0.0225 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 0.316 | uM | 72 | hr | 1 | 1112 | 52 | 0.0537 | 0.0545 | 0.0468 | 0.0467 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 0.316 | uM | 72 | hr | 2 | 1221 | 62 | 0.0587 | 0.0545 | 0.0508 | 0.0467 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 0.316 | uM | 72 | hr | 3 | 1056 | 45 | 0.0512 | 0.0545 | 0.0426 | 0.0467 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 1.000 | uM | 72 | hr | 1 | 1292 | 66 | 0.0621 | 0.0577 | 0.0511 | 0.0487 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 1.000 | uM | 72 | hr | 2 | 1173 | 45 | 0.0571 | 0.0577 | 0.0384 | 0.0487 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 1.000 | uM | 72 | hr | 3 | 1130 | 64 | 0.0540 | 0.0577 | 0.0566 | 0.0487 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 3.160 | uM | 72 | hr | 1 | 1388 | 90 | 0.0657 | 0.0636 | 0.0648 | 0.0545 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 3.160 | uM | 72 | hr | 2 | 1396 | 73 | 0.0670 | 0.0636 | 0.0523 | 0.0545 |
A-375 | Vemurafenib | Dasatinib | 0.316 | 3.160 | uM | 72 | hr | 3 | 1204 | 56 | 0.0581 | 0.0636 | 0.0465 | 0.0545 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.000 | uM | 72 | hr | 1 | 3774 | 124 | 0.1848 | 0.1953 | 0.0329 | 0.0349 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.000 | uM | 72 | hr | 2 | 3957 | 137 | 0.1934 | 0.1953 | 0.0346 | 0.0349 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.000 | uM | 72 | hr | 3 | 4259 | 158 | 0.2077 | 0.1953 | 0.0371 | 0.0349 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.316 | uM | 72 | hr | 1 | 982 | 130 | 0.0431 | 0.0433 | 0.1324 | 0.1382 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.316 | uM | 72 | hr | 2 | 1035 | 135 | 0.0456 | 0.0433 | 0.1304 | 0.1382 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 0.316 | uM | 72 | hr | 3 | 962 | 146 | 0.0413 | 0.0433 | 0.1518 | 0.1382 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 1.000 | uM | 72 | hr | 1 | 1021 | 134 | 0.0449 | 0.0398 | 0.1312 | 0.1218 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 1.000 | uM | 72 | hr | 2 | 954 | 137 | 0.0414 | 0.0398 | 0.1436 | 0.1218 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 1.000 | uM | 72 | hr | 3 | 717 | 65 | 0.0330 | 0.0398 | 0.0907 | 0.1218 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1188 | 84 | 0.0559 | 0.0490 | 0.0707 | 0.0884 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 2 | 967 | 88 | 0.0445 | 0.0490 | 0.0910 | 0.0884 |
A-375 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 3 | 1023 | 106 | 0.0464 | 0.0490 | 0.1036 | 0.0884 |
A-375 | Vemurafenib | Dasatinib | 3.160 | 0.000 | uM | 72 | hr | 1 | 3477 | 209 | 0.1655 | 0.1621 | 0.0601 | 0.0672 |
A-375 | Vemurafenib | Dasatinib | 3.160 | 0.000 | uM | 72 | hr | 2 | 3221 | 214 | 0.1523 | 0.1621 | 0.0664 | 0.0672 |