Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 3598 270 0.1685 0.1621 0.0750 0.0672
A-375 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 1025 184 0.0426 0.0433 0.1795 0.1874
A-375 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 1189 229 0.0486 0.0433 0.1926 0.1874
A-375 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 947 180 0.0388 0.0433 0.1901 0.1874
A-375 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1265 271 0.0503 0.0434 0.2142 0.1958
A-375 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 2 1025 203 0.0416 0.0434 0.1980 0.1958
A-375 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 914 160 0.0382 0.0434 0.1751 0.1958
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1196 197 0.0506 0.0492 0.1647 0.1635
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1138 197 0.0477 0.0492 0.1731 0.1635
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1153 176 0.0495 0.0492 0.1526 0.1635
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 18341 936 0.8341 0.8197 0.0510 0.0506
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 18747 969 0.8520 0.8197 0.0517 0.0506
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 9567 390 0.4398 0.4342 0.0408 0.0408
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 10229 430 0.4696 0.4342 0.0420 0.0408
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 8546 338 0.3934 0.4342 0.0396 0.0408
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 2168 298 0.0896 0.0889 0.1375 0.1262
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 2198 268 0.0925 0.0889 0.1219 0.1262
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 13441 248 0.6323 0.4565 0.0185 0.0200
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 8056 164 0.3782 0.4565 0.0204 0.0200
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 7654 162 0.3590 0.4565 0.0212 0.0200