Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10696.153 | uM | 3.74260 | 6.55580 | -0.2491 | -0.4480 | 1.1412 | 0.2180 | 0.9682 | 0.5484 | |
| BT-483 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10696.072 | uM | 43.20790 | 124.21610 | -0.1623 | -1.0000 | 1.0404 | 0.2141 | 0.8327 | 0.4643 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5908.074 | uM | 0.11113 | 0.64705 | -0.6393 | -0.7661 | 0.5274 | 0.8007 | 0.9563 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5908.074 | uM | 0.11113 | 0.64705 | -0.6393 | -0.7661 | 0.5274 | 0.8007 | 0.9563 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bosutinib | Src | nRTK | 11855.145 | uM | 3.66260 | 4.19030 | -0.8184 | -0.4801 | 5.0000 | 0.5661 | 0.6911 | 0.5070 | |
| BT-483 | HR+ | Luminal | Bosutinib | Src | nRTK | 10696.145 | uM | 3.13480 | 5.19110 | -0.6307 | -0.6346 | 1.6247 | 0.4785 | 0.9049 | 0.3316 | |
| BT-483 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9186.119 | uM | 1.27450 | 6.27310 | -0.8160 | -0.8306 | 0.6141 | 0.7359 | 0.9567 | 0.4743 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7801.018 | uM | inf | inf | 0.7533 | 0.7533 | 0.0000 | 0.1055 | 0.0672 | 0.5913 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9186.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5108 | |
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7801.018 | uM | 238.27260 | 938.7430 | -0.6364 | -1.0000 | 0.8013 | 0.3830 | 0.9170 | 0.5913 | ||
| BT-483 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9186.026 | uM | 888.46620 | 1000.00000 | -0.4363 | -0.4026 | 4.9950 | 0.1409 | 0.9905 | 0.5108 | ||
| BT-483 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9186.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0318 | -0.9738 | 0.6923 | |
| BT-483 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7801.035 | uM | 12.85250 | 21.64610 | -0.7852 | -0.8012 | 1.8347 | 0.3628 | 0.9913 | 0.5427 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 7801.007 | uM | 6.78250 | 44.12660 | -0.1528 | -1.0000 | 0.5866 | 0.2710 | 0.9323 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9186.121 | uM | 4.98180 | 5.43020 | -0.0147 | -0.0435 | 0.9683 | 0.2003 | 0.9724 | 0.8379 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10696.146 | uM | inf | inf | 0.3479 | 0.3479 | 0.0000 | 0.2317 | 0.5420 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 11855.155 | uM | 0.03457 | 0.07069 | 0.0319 | -0.1258 | 0.3137 | 0.5465 | 0.8209 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13130.176 | uM | inf | inf | 0.8165 | 0.8165 | 0.0000 | 0.1820 | -0.3994 | 0.4942 | |
| BT-483 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13130.174 | uM | inf | inf | 0.4475 | 0.4475 | 0.0000 | 0.2415 | 0.3128 | 0.5126 | |
| BT-483 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 7801.002 | uM | 0.01645 | 0.01685 | -0.2388 | -0.0639 | 5.0000 | 0.5115 | 0.9648 | 0.4140 | |
| BT-483 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9186.002 | uM | 0.02228 | 0.01940 | 0.0839 | 0.1113 | 1.8218 | 0.4052 | 0.9887 | 0.4768 | |
| BT-483 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9186.121 | uM | 0.47146 | 0.49282 | -0.4016 | -0.0552 | 2.3648 | 0.4253 | 0.8887 | 0.8379 | |
| BT-483 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7801.007 | uM | 0.12760 | 0.44625 | -0.7325 | -0.6256 | 0.6481 | 0.6864 | 0.8956 | 0.6446 | |
| BT-483 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7801.035 | uM | 0.19123 | 0.34229 | -0.9999 | -0.5532 | 1.2796 | 0.7517 | 0.8977 | 0.5427 | |
| BT-483 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 5908.091 | uM | inf | inf | 0.4165 | 0.4165 | 0.0000 | 0.2646 | 0.1158 | 0.5109 |