Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
BT-474
HER2amp
Luminal
 5-DFUR
TYMS
TYMS
12291.143
uM
252.60420
1000.00000
 -0.2515 -0.6987 0.6355 0.3058
0.9375
 0.5621
BT-474
HER2amp
Luminal
 5-FU
TYMS
TYMS
7798.017
uM
688.02420
1000.00000
 -0.1296 -0.1902 0.8622 0.2785
0.9937
 1.4161
BT-474
HER2amp
Luminal
 5-FU
TYMS
TYMS
9163.03
uM
48.43290
158.3510
 -0.9949 -1.0000 0.9274 0.7288
0.9942
 0.3535
BT-474
HER2amp
Luminal
 Afatinib
EGFR/HER2
ErbB
12291.165
uM
0.00084
0.00487
 -0.9997 -1.0000 0.6233 1.4610
0.9623
 0.5602
BT-474
HER2amp
Luminal
 Afatinib
EGFR/HER2
ErbB
12056.158
uM
0.00506
0.01885
 -0.9829 -0.8526 0.7565 1.1618
0.9747
 0.9929
BT-474
HER2amp
Luminal
 Afatinib
EGFR/HER2
ErbB
12178.158
uM
0.00866
0.02277
 -0.9958 -0.8611 1.0356 1.1447
0.9876
 0.7379
BT-474
HER2amp
Luminal
 AG1024
IGF1R
RTK
5905.066
uM
51.41880
37.45740
 0.7848 0.3974 4.9993 -0.0224
0.7370
 0.7639
BT-474
HER2amp
Luminal
 AG1024
IGF1R
RTK
5906.066
uM
33.66570
35.23930
 0.5150 -0.1278 4.9808 0.0345
0.9174
 0.7892
BT-474
HER2amp
Luminal
 AG1478
EGFR
ErbB
7797.016
uM
0.51143
2.28560
 -0.7160 -0.8499 0.6634 0.6441
0.9866
 0.5155
BT-474
HER2amp
Luminal
 AS-252424
PI3K
PI3K
12178.158
uM
inf
inf
 0.0271 0.0271 0.0000 0.1623
0.5062
 0.7379
BT-474
HER2amp
Luminal
 AS-252424
PI3K
PI3K
12291.165
uM
0.41097
147.3160
 -0.1202 -1.0000 0.1868 0.4109
0.6135
 0.5602
BT-474
HER2amp
Luminal
 AS-252424
PI3K
PI3K
12056.158
uM
37.4280
186.27620
 0.2787 -1.0000 0.6846 0.1418
0.7436
 0.9929
BT-474
HER2amp
Luminal
 Baicalein
Lipoxygenase
Metabolism
5905.073
uM
87.59360
52.36220
 0.4601 0.4581 4.8173 0.0010
0.9448
 0.8600
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5905.074
uM
0.02423
0.07603
 -0.8680 -0.7730 0.8171 1.0382
0.9561
 0.8648
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5905.074
uM
0.02423
0.07603
 -0.8680 -0.7730 0.8171 1.0382
0.9561
 0.8648
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
14825.203
uM
0.00933
0.01354
 -0.8853 -0.7370 2.4340 1.1414
0.9756
 0.5604
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
14825.203
uM
0.00933
0.01354
 -0.8853 -0.7370 2.4340 1.1414
0.9756
 0.5604
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5906.074
uM
0.04174
0.08720
 -0.9015 -0.7872 1.2835 1.0213
0.9815
 0.6442
BT-474
HER2amp
Luminal
 Bortezomib
Proteasome
Proteasome
5906.074
uM
0.04174
0.08720
 -0.9015 -0.7872 1.2835 1.0213
0.9815
 0.6442
BT-474
HER2amp
Luminal
 Bosutinib
Src
nRTK
12291.17
uM
0.30452
1.97420
 -0.5742 -0.9844 0.5822 0.5621
0.8516
 0.5585
BT-474
HER2amp
Luminal
 Bosutinib
Src
nRTK
12056.145
uM
1.24670
2.91970
 -0.7356 -0.6938 1.0227 0.5761
0.8832
 0.8365
BT-474
HER2amp
Luminal
 Bosutinib
Src
nRTK
12178.145
uM
1.82530
2.51750
 -0.0897 -0.1691 0.9060 0.3941
0.9217
 0.6127
BT-474
HER2amp
Luminal
 Bromopyruvic acid
Hexokinase II
Metabolism
13125.177
uM
0.37090
0.53838
 -1.0000 -0.9928 2.9354 0.6307
0.9967
 0.8991
BT-474
HER2amp
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
9158.12
uM
83.56440
129.50480
 -0.9450 -0.9509 2.4317 0.3689
0.9767
 0.7176
BT-474
HER2amp
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
9163.011
uM
92.88920
177.40340
 -0.9636 -1.0000 1.6980 0.2967
0.9963
 0.6266