Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9157.021 | uM | 184.09220 | 293.84270 | -0.7173 | -0.7945 | 2.0344 | 0.2238 | 0.9984 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7798.018 | uM | inf | inf | 1.0028 | 1.0028 | 0.0000 | -0.0260 | -0.7402 | 1.4461 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9158.123 | uM | inf | inf | 0.7610 | 0.7610 | 0.0000 | 0.0813 | 0.5069 | 0.8769 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9163.026 | uM | inf | 0.00002 | 0.8122 | 0.8820 | 4.9564 | 0.0838 | 0.5768 | 0.3738 | |
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9157.034 | uM | 162.90980 | 696.84330 | -0.9646 | -1.0000 | 0.7559 | 0.4501 | 0.8634 | 1.0593 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9163.026 | uM | 1.16670 | 17.90580 | -1.0000 | -1.0000 | 0.4023 | 0.8897 | 0.9004 | 0.3738 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7798.018 | uM | 525.74440 | 1000.00000 | -0.8409 | -0.8472 | 1.5417 | 0.3015 | 0.9118 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9158.123 | uM | 3.16810 | 8.29940 | -0.9937 | -1.0000 | 1.1408 | 0.4810 | 0.9711 | 0.8769 | ||
| BT-474 | HER2amp | Luminal | Chloroquine | 13125.177 | uM | 16.18740 | 20.98530 | -0.9865 | -1.0000 | 4.2322 | 0.2522 | 0.8943 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9158.049 | uM | inf | inf | 0.6224 | 0.6224 | 0.0000 | 0.1163 | 0.1803 | 0.4082 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9157.021 | uM | 23.17430 | 33.94590 | -0.6064 | -0.6289 | 2.1334 | 0.2708 | 0.9906 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7798.017 | uM | 42.03470 | 54.44580 | -0.3785 | -0.4172 | 2.3450 | 0.1701 | 0.9912 | 1.4161 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9163.03 | uM | 26.3970 | 32.88280 | -0.9993 | -0.9998 | 5.0000 | 0.3249 | 0.9959 | 0.3535 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7798.077 | uM | inf | inf | 0.8883 | 0.8883 | 0.0000 | -0.0257 | 0.4190 | 1.4371 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9157.034 | uM | inf | 22.39670 | 0.5995 | 0.5981 | 4.7252 | 0.0387 | 0.8844 | 1.0593 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9158.121 | uM | 79.32990 | 90.15240 | 0.3780 | -0.4458 | 4.9841 | 0.0249 | 0.9360 | 1.0691 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9163.121 | uM | 8.67210 | 8.14520 | 0.1227 | 0.1345 | 4.9990 | 0.1211 | 0.9838 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12291.155 | uM | inf | inf | 0.8638 | 0.8638 | 0.0000 | 0.1956 | 0.2806 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12056.155 | uM | inf | inf | 0.5364 | 0.5364 | 0.0000 | 0.4338 | 0.3640 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12178.155 | uM | inf | inf | 0.5782 | 0.5782 | 0.0000 | 0.4091 | 0.3793 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13125.176 | uM | inf | inf | 0.8740 | 0.8740 | 0.0000 | 0.0169 | 0.4953 | 0.8351 | |
| BT-474 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13125.174 | uM | inf | inf | 0.6222 | 0.6222 | 0.0000 | 0.1712 | 0.3674 | 0.9685 | |
| BT-474 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9163.002 | uM | 0.00526 | 0.00708 | -0.7196 | -0.6636 | 2.8432 | 0.9540 | 0.9913 | 0.6004 | |
| BT-474 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9157.002 | uM | 0.00636 | 0.00725 | -0.1096 | -0.1132 | 1.5556 | 0.6222 | 0.9965 | 0.9306 | |
| BT-474 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9158.002 | uM | 0.00673 | 0.00919 | -0.7179 | -0.7087 | 2.8401 | 0.9182 | 0.9979 | 0.4298 |