Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | IKK16 | IKK | NFKB | 5904.1 | uM | 3.2630 | 4.78830 | -0.9364 | -0.9398 | 2.7575 | 0.4257 | 0.9913 | 1.3369 | |
| BT-20 | TNBC | Basal A | IKK16 | IKK | NFKB | 10385.093 | uM | 3.54330 | 4.41410 | -0.9989 | -1.0000 | 4.9997 | 0.3819 | 0.9982 | 0.6082 | |
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5904.092 | uM | 7.68060 | 18.45430 | -0.9954 | -1.0000 | 1.2533 | 0.6283 | 0.9466 | 0.8933 | |
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5903.09 | uM | 14.23390 | 26.11670 | -0.9964 | -1.0000 | 1.8101 | 0.5188 | 0.9862 | 0.9291 | |
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5902.091 | uM | 25.1560 | 35.74990 | -0.9699 | -0.9762 | 3.0805 | 0.4234 | 0.9972 | 1.1648 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 5902.067 | uM | 0.02739 | 0.47554 | -0.9786 | -1.0000 | 0.3849 | 0.6756 | 0.8442 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 5903.067 | uM | 0.01561 | 0.02594 | -0.9863 | -0.4826 | 1.3299 | 0.8003 | 0.9066 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 5904.067 | uM | 0.01503 | 0.02069 | -0.9957 | -0.5464 | 2.3099 | 0.8668 | 0.9421 | 1.0398 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 10385.095 | uM | 0.00319 | 0.00514 | -0.9980 | -0.5798 | 1.6199 | 1.0590 | 0.9374 | 0.7986 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 5902.095 | uM | 0.00775 | 0.01266 | -0.9806 | -0.5587 | 1.5290 | 0.9318 | 0.9485 | 1.0245 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 5904.095 | uM | 0.00177 | 0.00213 | -0.9973 | -0.7751 | 4.9993 | 1.3519 | 0.9867 | 0.6537 | |
| BT-20 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 10581.144 | uM | 1.46850 | 1.58040 | -0.3485 | -0.2218 | 5.0000 | 0.4645 | 0.9194 | 1.2048 | |
| BT-20 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 11854.144 | uM | 0.55999 | 0.64447 | -0.2555 | -0.2061 | 2.4565 | 0.4840 | 0.9967 | 1.3102 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10581.137 | uM | inf | 10.00460 | 0.5092 | 0.5077 | 4.7765 | 0.0869 | 0.7337 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 11854.161 | uM | 34.51650 | 42.99810 | -0.3604 | -1.0000 | 5.0000 | 0.0676 | 0.9896 | 1.2085 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 5902.098 | uM | inf | inf | 0.9860 | 0.9860 | 0.0000 | -0.0045 | -0.0403 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 5904.098 | uM | inf | inf | 0.8819 | 0.8819 | 0.0000 | 0.0368 | 0.3491 | 1.3264 | |
| BT-20 | TNBC | Basal A | LBH589 | HDAC | HDAC | 11854.154 | uM | 0.35741 | 0.53161 | -0.6250 | -0.5778 | 1.9345 | 0.5130 | 0.9932 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11854.154 | uM | 3.30110 | 6.51830 | -0.9271 | -1.0000 | 1.6148 | 0.3215 | 0.9831 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10581.142 | uM | 2.83260 | 4.6630 | -0.9968 | -1.0000 | 2.2041 | 0.5323 | 0.9899 | 0.7885 | |
| BT-20 | TNBC | Basal A | Mebendazole | 13579.174 | uM | 0.58296 | 2.17040 | -0.7093 | -0.7012 | 0.6667 | 0.4704 | 0.8992 | 0.8018 | |||
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5904.085 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0334 | -1.4110 | 1.2247 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5902.084 | uM | inf | inf | 0.9945 | 0.9945 | 0.0000 | -0.0077 | -0.0317 | 1.3532 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5903.084 | uM | inf | inf | 1.0102 | 1.0102 | 0.0000 | 0.0105 | 0.0000 | 1.2088 | |
| BT-20 | TNBC | Basal A | Methylglyoxal | 13599.184 | uM | 500.64850 | 581.97960 | -0.9120 | -0.5613 | 5.0000 | 0.6654 | 0.8086 | 0.8566 |