Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
BT-474
HER2amp
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12178.154
uM
0.27381
1.07140
 -0.9994 -1.0000 0.8053 0.5291
0.9912
 0.5170
BT-474
HER2amp
Luminal
 Mebendazole
13125.174
uM
0.25333
0.32539
 -0.2292 -0.1705 1.1722 0.5214
0.9620
 0.9685
BT-474
HER2amp
Luminal
 Methotrexate
DHFR
Metabolism
5905.085
uM
inf
inf
 0.8672 0.8672 0.0000 0.0580
0.2028
 0.8847
BT-474
HER2amp
Luminal
 Methotrexate
DHFR
Metabolism
5906.084
uM
inf
303.25410
 0.7604 0.6095 4.9155 -0.0227
0.7577
 0.5452
BT-474
HER2amp
Luminal
 Methylglyoxal
13492.184
uM
377.06610
1000.00000
 -0.9884 -0.9163 1.0675 0.6077
0.9794
 0.9589
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12291.17
uM
0.12484
0.27537
 -0.9700 -0.9645 1.3584 0.9727
0.8824
 0.5585
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12291.17
uM
0.12484
0.27537
 -0.9700 -0.9645 1.3584 0.9727
0.8824
 0.5585
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14233.189
uM
0.22157
0.26649
 -0.9860 -0.6472 4.4996 0.7714
0.9113
 0.3780
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14233.189
uM
0.22157
0.26649
 -0.9860 -0.6472 4.4996 0.7714
0.9113
 0.3780
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14119.189
uM
0.45401
0.55980
 -0.5255 -0.2404 1.8744 0.5108
0.9232
 1.2143
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14119.189
uM
0.45401
0.55980
 -0.5255 -0.2404 1.8744 0.5108
0.9232
 1.2143
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12056.145
uM
0.13025
0.53653
 -0.8881 -0.9546 0.7543 0.7866
0.9644
 0.8365
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12056.145
uM
0.13025
0.53653
 -0.8881 -0.9546 0.7543 0.7866
0.9644
 0.8365
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12178.145
uM
0.19387
0.45401
 -0.9242 -0.8866 1.1987 0.7405
0.9861
 0.6127
BT-474
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12178.145
uM
0.19387
0.45401
 -0.9242 -0.8866 1.1987 0.7405
0.9861
 0.6127
BT-474
HER2amp
Luminal
 Pevonedistat
NAE1
NAE1
12291.135
uM
0.08638
0.22094
 -0.7077 -0.6132 0.8522 0.7665
0.8721
 0.4536
BT-474
HER2amp
Luminal
 Pevonedistat
NAE1
NAE1
12056.135
uM
0.46758
1.24480
 0.0078 -0.2350 0.3935 0.4344
0.9402
 0.9361
BT-474
HER2amp
Luminal
 Pevonedistat
NAE1
NAE1
12178.135
uM
0.64786
0.74150
 -0.0898 -0.0657 0.9144 0.3414
0.9662
 0.5524
BT-474
HER2amp
Luminal
 Nelfinavir
13125.174
uM
10.470
16.79570
 -0.6639 -1.0000 2.3245 0.2049
0.9671
 0.9685
BT-474
HER2amp
Luminal
 Nilotinib
ABL
nRTK
12178.145
uM
inf
inf
 1.0500 1.0500 0.0000 0.0369
0.0948
 0.6127
BT-474
HER2amp
Luminal
 Nilotinib
ABL
nRTK
12291.17
uM
inf
inf
 0.6458 0.6458 0.0000 0.2392
0.3142
 0.5585
BT-474
HER2amp
Luminal
 Nilotinib
ABL
nRTK
12056.145
uM
inf
inf
 0.9538 0.9538 0.0000 0.0958
0.3538
 0.8365
BT-474
HER2amp
Luminal
 NSC 663284
CDC25
CDC
12291.152
uM
1.41260
2.14060
 -0.9965 -1.0000 2.6431 0.7780
0.9658
 0.6792
BT-474
HER2amp
Luminal
 NSC 663284
CDC25
CDC
12056.159
uM
1.96790
2.96510
 -0.9859 -0.9887 2.6614 0.7177
0.9745
 0.9145
BT-474
HER2amp
Luminal
 NSC 663284
CDC25
CDC
12178.159
uM
3.55760
4.43060
 -0.9977 -0.9980 5.0000 0.5758
0.9978
 0.6130