Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
BT-20	TNBC	Basal A	Etoposide	TOP2	TOP	5904.074	uM	1.46090	2.86370	-0.6922	-0.6187	1.1965	0.5743	0.9944	0.9654
BT-20	TNBC	Basal A	Etoposide	TOP2	TOP	5903.074	uM	3.12940	6.05040	-0.6843	-0.6777	1.2994	0.5294	0.9965	1.0729
BT-20	TNBC	Basal A	Etoposide	TOP2	TOP	5902.074	uM	7.33850	12.76730	-0.5843	-0.5903	1.4078	0.4030	0.9980	1.2939
BT-20	TNBC	Basal A	Everolimus	MTOR	MTOR	11854.156	uM	1.24980	37.35920	-0.2730	-1.0000	0.3234	0.3498	0.8136	1.0916
BT-20	TNBC	Basal A	Fascaplysin	CDK4	CDK	5902.084	uM	0.30696	0.43855	-0.9350	-0.9346	2.9546	0.6463	0.9973	1.3532
BT-20	TNBC	Basal A	Fascaplysin	CDK4	CDK	5903.084	uM	0.32440	0.44114	-0.9762	-0.9684	3.5047	0.6548	0.9986	1.2088
BT-20	TNBC	Basal A	Fascaplysin	CDK4	CDK	5904.085	uM	0.15202	0.18790	-0.9724	-0.9426	5.0000	0.8009	0.9987	1.2247
BT-20	TNBC	Basal A	FR180204	ERK1/2	MAPK	10581.137	uM	inf	inf	0.6954	0.6954	0.0000	0.0778	0.4171	1.1975
BT-20	TNBC	Basal A	FR180204	ERK1/2	MAPK	11854.161	uM	100.53860	466.86010	0.4990	-1.0000	0.7155	0.1017	0.7789	1.2085
BT-20	TNBC	Basal A	FTase Inhibitor I	Ftase	MAPK	10581.142	uM	inf	inf	0.9722	0.9722	0.0000	0.0008	-0.0078	0.7885
BT-20	TNBC	Basal A	FTase Inhibitor I	Ftase	MAPK	11854.154	uM	inf	inf	0.8747	0.8747	0.0000	0.1104	0.0000	1.3146
BT-20	TNBC	Basal A	Glycyl-H-1152	ROCK2		10581.138	uM	3.99210	1.62710	0.3189	0.2906	0.9695	0.2155	0.8715	0.9462
BT-20	TNBC	Basal A	Glycyl-H-1152	ROCK2		11854.16	uM	16.0370	2.7590	0.4372	0.3982	0.9041	0.1619	0.9739	1.3102
BT-20	TNBC	Basal A	GM6001	MMP	MMP	5904.096	uM	inf	7.15520	0.6480	0.6209	1.6671	0.0210	0.9187	0.9724
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5902.071	uM	inf	inf	-0.1081	-0.1081	0.0000	0.1032	0.4127	1.1197
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5904.092	uM	3.28720	3.79520	-0.6269	-0.5258	5.0000	0.4054	0.9175	0.8933
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5902.091	uM	8.57440	9.75240	-0.8214	-0.4516	4.9993	0.2793	0.9194	1.1648
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5904.098	uM	26.34060	35.92560	0.3268	-0.1218	0.7025	0.1237	0.9449	1.3264
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5902.098	uM	59.24040	58.84580	0.4071	0.0106	3.2109	0.0313	0.9651	1.1137
BT-20	TNBC	Basal A	GSK1838705A	IGF1R	RTK	5903.09	uM	6.69250	56.66960	-0.2321	-1.0000	0.5143	0.3031	0.9810	0.9291
BT-20	TNBC	Basal A	GW843682X	PLK	PLK	10581.139	uM	inf	inf	0.8086	0.8086	0.0000	0.1131	0.1274	1.1488
BT-20	TNBC	Basal A	Ibandronate	FDPS		10581.143	uM	16.48930	71.54520	-0.9002	-1.0000	0.7486	0.5729	0.9168	0.9062
BT-20	TNBC	Basal A	Ibandronate	FDPS		11854.143	uM	23.23980	57.24720	-0.7762	-0.7731	1.0367	0.4277	0.9918	1.1185
BT-20	TNBC	Basal A	ICRF-193	TOP2	TOP	11854.157	uM	inf	999.98080	0.6961	0.3833	0.1063	0.1693	0.6089	1.4808
BT-20	TNBC	Basal A	ICRF-193	TOP2	TOP	10581.139	uM	inf	999.99980	0.5741	0.0614	0.1420	0.1990	0.6409	1.1488

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)