Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
600MPE
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9118.011
uM
12.80430
29.13070
 -0.5219 -0.6603 1.0241 0.4039
0.9835
 1.0538
600MPE
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9120.021
uM
16.89330
40.58020
 -0.9570 -1.0000 1.2536 0.4435
0.9886
 0.6486
600MPE
HR+
Luminal
 Oxamflatin
HDAC
HDAC
12224.147
uM
2.79220
7.38130
 -0.9880 -1.0000 1.1301 0.3828
0.9872
 0.8621
600MPE
HR+
Luminal
 PD 98059
MEK
MAPK
12224.152
uM
124.1750
739.75820
 0.6747 -1.0000 0.6156 0.0605
0.8626
 1.0761
600MPE
HR+
Luminal
 PD173074
FGFR1/3
RTK
5898.093
uM
7.82560
10.48720
 -0.9800 -1.0000 3.7527 0.3030
0.9267
 0.6963
600MPE
HR+
Luminal
 PD184352
MEK
MAPK
12224.155
uM
inf
inf
 0.6879 0.6879 0.0000 0.1877
0.1373
 1.0378
600MPE
HR+
Luminal
 PD184352
MEK
MAPK
12224.155
uM
inf
inf
 0.6879 0.6879 0.0000 0.1877
0.1373
 1.0378
600MPE
HR+
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
5899.094
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0167
-0.1754
 1.0334
600MPE
HR+
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
5898.095
uM
inf
inf
 0.3076 0.3076 0.0000 0.6877
0.0000
 0.6975
600MPE
HR+
Luminal
 PS-1145
IKK
NFKB
5898.065
uM
inf
inf
 0.9898 0.9898 0.0000 0.1430
0.0000
 0.6845
600MPE
HR+
Luminal
 PS-1145
IKK
NFKB
5899.065
uM
inf
inf
 0.8491 0.8491 0.0000 0.1182
0.0000
 1.0946
600MPE
HR+
Luminal
 Purvalanol A
CDK1
CDK
5898.067
uM
inf
inf
 0.8837 0.8837 0.0000 0.0867
0.1356
 0.6532
600MPE
HR+
Luminal
 Purvalanol A
CDK1
CDK
5899.067
uM
27.81920
110.71190
 -0.1721 -1.0000 0.7954 0.2510
0.9003
 0.9897
600MPE
HR+
Luminal
 QNZ
NFkB
NFKB
5898.096
uM
inf
0.06585
 0.6881 0.6711 4.7174 0.1528
0.9145
 0.6718
600MPE
HR+
Luminal
 SB-3CT
MMP2/9
MMP
12224.144
uM
inf
inf
 0.8442 0.8442 0.0000 0.1370
-0.1637
 1.0210
600MPE
HR+
Luminal
 Selumetinib
MEK
MAPK
12224.155
uM
0.53417
0.10230
 0.2888 0.3014 0.5585 0.3322
0.9653
 1.0378
600MPE
HR+
Luminal
 Sigma A6730
AKT
AKT
12224.165
uM
6.5660
13.29760
 -0.9371 -1.0000 1.5568 0.3611
0.9610
 0.9714
600MPE
HR+
Luminal
 Sirolimus
MTOR
MTOR
7791.068
uM
0.15062
0.04002
 -0.0209 0.1737 0.3221 0.4926
0.7333
 0.8032
600MPE
HR+
Luminal
 Sirolimus
MTOR
MTOR
5899.068
uM
inf
0.02668
 0.5818 0.6451 2.3199 0.2344
0.9310
 1.0389
600MPE
HR+
Luminal
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
5899.084
uM
211.34090
1000.00000
 0.1706 -0.4320 0.4006 0.1910
0.7174
 1.1144
600MPE
HR+
Luminal
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
5898.085
uM
57.26150
86.20510
 -0.9896 -1.0000 2.6854 0.3512
0.9042
 0.7048
600MPE
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
5898.067
uM
5.29710
7.53220
 -0.9986 -1.0000 3.1208 0.5757
0.9370
 0.6532
600MPE
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
5899.067
uM
2.37830
4.93120
 -0.9995 -1.0000 1.5066 0.6079
0.9889
 0.9897
600MPE
HR+
Luminal
 TAPI-0
TACE/Collagenase
5898.096
uM
89.24790
597.73340
 0.6770 -0.9738 0.5684 0.0541
0.9121
 0.6718
600MPE
HR+
Luminal
 Taxol
TUBB
TUBB
9118.002
uM
0.07399
0.02651
 0.3917 0.3920 1.4923 0.3215
0.9870
 0.9880