Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7821.05 | uM | 0.04804 | 0.06835 | -0.9999 | -0.9295 | 2.9796 | 1.0943 | 0.9946 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7821.016 | uM | 0.87254 | 1.1560 | -0.3806 | -0.4291 | 2.2024 | 0.5987 | 0.9512 | 0.3100 | |
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7821.016 | uM | inf | inf | 0.6910 | 0.6910 | 0.0000 | 0.1510 | 0.2609 | 0.3100 | ||
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7821.016 | uM | 1.03540 | 2.87430 | -0.9194 | -1.0000 | 1.0760 | 0.3518 | 0.9801 | 0.3100 | |
| HCC70 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 12714.176 | uM | 0.59743 | 168.50620 | 0.2521 | -1.0000 | 0.1947 | 0.2769 | 0.5769 | 0.3108 | |
| UACC-812 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10267.026 | uM | inf | inf | -0.0483 | -0.0483 | 0.0000 | 0.2444 | 0.3347 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10267.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0438 | -8.1346 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10267.026 | uM | 15.170 | 207.56150 | -0.9994 | -1.0000 | 0.4199 | 0.5813 | 0.7864 | 0.3125 | ||
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 9420.012 | uM | 11.78230 | 14.67580 | -0.3118 | -0.9991 | 5.0000 | 0.2592 | 0.6528 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9420.012 | uM | 0.01386 | 0.01703 | -0.9643 | -0.9044 | 5.0000 | 1.3001 | 0.9964 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 10996.153 | uM | 0.80696 | 1.86130 | -0.9987 | -0.9947 | 1.3103 | 0.6148 | 0.9761 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 10996.153 | uM | 1.80440 | 3.40920 | -0.4709 | -0.5709 | 1.1971 | 0.3091 | 0.9826 | 0.3186 | |
| MDA-MB-361 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 12379.147 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.2178 | 0.2648 | 0.3192 | |
| MDA-MB-361 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 12379.147 | uM | 7.59720 | 9.86240 | -0.9832 | -0.9829 | 4.1662 | 0.4715 | 0.8611 | 0.3192 | |
| MDA-MB-361 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 12379.147 | uM | 1.70740 | 2.12590 | -1.0000 | -0.9966 | 5.0000 | 0.6457 | 0.9056 | 0.3192 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 9044.067 | uM | 0.01283 | 0.01597 | -1.0000 | -0.9908 | 4.9982 | 1.3236 | 0.7375 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 9044.067 | uM | 0.05573 | 1.21580 | -1.0000 | -1.0000 | 0.3564 | 0.8720 | 0.5906 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 9044.067 | uM | inf | inf | -0.2355 | -0.2355 | 0.0000 | 0.4250 | 0.1569 | 0.3210 | |
| 184B5 | NM | Basal | Sirolimus | MTOR | MTOR | 7789.068 | uM | inf | inf | -0.9304 | -0.9304 | 0.0000 | 1.0723 | 0.4470 | 0.3219 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7848.017 | uM | 418.4950 | 571.66450 | -0.7572 | -0.6622 | 2.7044 | 0.4233 | 0.9935 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 7848.017 | uM | 0.17714 | 0.50367 | -1.0000 | -1.0000 | 1.0513 | 0.9005 | 0.9933 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7848.017 | uM | 2.61350 | 5.15150 | -1.0000 | -1.0000 | 1.6190 | 0.5752 | 0.9974 | 0.3225 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10151.034 | uM | 2.18960 | 2.47240 | -0.6914 | -0.4143 | 4.9682 | 0.3383 | 0.9554 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10151.034 | uM | 2.57870 | 64.17660 | -1.0000 | -1.0000 | 0.3418 | 0.7599 | 0.7768 | 0.3226 | ||
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 10151.034 | uM | 0.04740 | 0.10608 | -1.0000 | -1.0000 | 1.3638 | 1.0938 | 0.9616 | 0.3226 |