Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
SUM185PE
TNBC
Luminal
 GSK1838705A
IGF1R
RTK
7532.098
uM
2.29380
3.63270
 -0.9972 -1.0000 2.3895 0.5839
0.9418
 0.6992
MDA-MB-361
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12379.17
uM
0.20473
0.28471
 -0.9971 -0.9845 3.2999 0.8508
0.9994
 0.5805
HCC70
TNBC
Basal A
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7860.011
uM
6.49970
9.5290
 -0.9971 -0.9987 2.8694 0.6551
0.9973
 0.7135
MDA-MB-157
TNBC
Basal B
 Chloroquine
12632.177
uM
1.67050
3.57270
 -0.9971 -1.0000 1.4452 0.4610
0.9970
 0.6753
HCC1428
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
7442.092
uM
19.2520
27.09720
 -0.9971 -1.0000 3.2141 0.4724
0.9966
 0.7831
MDA-MB-361
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
12379.17
uM
0.20473
0.28471
 -0.9971 -0.9845 3.2999 0.8508
0.9994
 0.5805
HCC1419
HER2amp
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
10019.12
uM
9.94530
28.0190
 -0.9970 -1.0000 1.0607 0.5208
0.9649
 0.4898
HCC1419
HER2amp
Luminal
 17-AAG
HSP90
HSP90
7820.05
uM
0.09953
0.12156
 -0.9970 -0.8586 5.0000 1.0211
0.9799
 0.4219
HCC1395
TNBC
Basal B
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12000.167
uM
0.07778
0.49446
 -0.9970 -1.0000 0.5940 0.6862
0.9736
 0.7185
UACC-812
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
11938.145
uM
0.12429
0.24022
 -0.9970 -1.0000 1.6673 0.9860
0.9564
 0.7062
UACC-812
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
11938.145
uM
0.12429
0.24022
 -0.9970 -1.0000 1.6673 0.9860
0.9564
 0.7062
BT-483
HR+
Luminal
 Afatinib
EGFR/HER2
ErbB
11855.158
uM
0.79652
3.89470
 -0.9969 -1.0000 0.6922 0.6114
0.8444
 0.6941
MX1
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10874.154
uM
0.06032
0.34228
 -0.9969 -1.0000 0.6329 0.7495
0.9768
 0.7639
HCC38
TNBC
Basal B
 IKK16
IKK
NFKB
10418.093
uM
2.8280
3.64580
 -0.9969 -0.9995 4.3238 0.4160
0.9980
 0.9872
HCC1419
HER2amp
Luminal
 NSC 663284
CDC25
CDC
12001.159
uM
1.55690
3.25510
 -0.9969 -1.0000 1.4896 0.6941
0.9585
 0.7107
UACC-812
HER2amp
Luminal
 Olomoucine II
CDK1
CDK
11938.147
uM
5.620
7.54930
 -0.9969 -1.0000 3.7226 0.5772
0.9236
 0.6765
MB 157
Unknown
Unknown
 Topotecan
TOP1
TOP
9039.078
uM
0.00994
0.03355
 -0.9969 -1.0000 0.9028 1.2872
0.9855
 0.6306
HCC1428
HR+
Luminal
 Vinorelbine
TUBB
TUBB
9294.125
uM
0.47685
3.59210
 -0.9968 -1.0000 0.5441 0.8355
0.8522
 0.6999
MDA-MB-361
HER2amp
Luminal
 GSK1838705A
IGF1R
RTK
7508.091
uM
38.62090
48.11130
 -0.9968 -1.0000 5.0000 0.2165
0.9652
 0.6662
HCC1187
TNBC
Basal A
 Taxol
TUBB
TUBB
9244.002
uM
0.00722
0.00898
 -0.9968 -0.9950 5.0000 1.2989
0.9984
 0.5206
BT-20
TNBC
Basal A
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10581.142
uM
2.83260
4.6630
 -0.9968 -1.0000 2.2041 0.5323
0.9899
 0.7885
T47D
HR+
Luminal
 Ixabepilone
TUBB
TUBB
7543.095
uM
inf
inf
 -0.9968 -0.9968 0.0000 0.7292
0.5683
 1.1854
SUM185PE
TNBC
Luminal
 Bortezomib
Proteasome
Proteasome
15332.203
uM
0.00634
0.00850
 -0.9967 -0.9967 3.7282 1.4136
0.9927
 0.7106
600MPE
HR+
Luminal
 Ixabepilone
TUBB
TUBB
5898.095
uM
0.05465
2.31930
 -0.9967 -1.0000 0.2931 0.5721
0.6309
 0.6975
SUM185PE
TNBC
Luminal
 Bortezomib
Proteasome
Proteasome
15332.203
uM
0.00634
0.00850
 -0.9967 -0.9967 3.7282 1.4136
0.9927
 0.7106