Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 12178.159 | uM | 3.55760 | 4.43060 | -0.9977 | -0.9980 | 5.0000 | 0.5758 | 0.9978 | 0.6130 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7441.084 | uM | 0.04994 | 0.06216 | -0.9976 | -0.9943 | 5.0000 | 0.9412 | 0.9996 | 0.8431 | |
| SUM1315MO2 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12428.165 | uM | 4.75260 | 11.16850 | -0.9976 | -1.0000 | 1.2858 | 0.3199 | 0.9814 | 0.7051 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 10267.121 | uM | 0.02610 | 0.03070 | -0.9975 | -0.6117 | 4.9211 | 0.9985 | 0.9109 | 0.4135 | |
| MDA-MB-134-VI | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10077.121 | uM | 1.34490 | 1.83630 | -0.9975 | -0.9923 | 3.5115 | 0.6376 | 0.9882 | 0.4875 | |
| SUM1315MO2 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 10875.144 | uM | 0.08860 | 2.28190 | -0.9975 | -1.0000 | 0.3382 | 0.7166 | 0.8682 | 0.7785 | |
| UACC-812 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10150.021 | uM | 2.80010 | 7.40680 | -0.9974 | -1.0000 | 1.1294 | 0.6039 | 0.9592 | 0.4883 | |
| HCC2185 | TNBC | Luminal | Afatinib | EGFR/HER2 | ErbB | 12192.158 | uM | 1.23320 | 3.12870 | -0.9974 | -1.0000 | 1.1800 | 0.5426 | 0.9697 | 0.6680 | |
| HCC1395 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9258.011 | uM | 8.63850 | 22.84430 | -0.9974 | -1.0000 | 1.1297 | 0.6494 | 0.9947 | 0.6984 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7441.067 | uM | 4.44990 | 8.2370 | -0.9974 | -1.0000 | 1.7842 | 0.5285 | 0.9786 | 0.8233 | |
| HCC1419 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7437.067 | uM | inf | inf | -0.9973 | -0.9973 | 0.0000 | 0.2089 | 0.4251 | 0.4038 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7876.017 | uM | 0.90344 | 1.11330 | -0.9973 | -0.9208 | 5.0000 | 0.9405 | 0.8510 | 0.6706 | |
| HCC1395 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9254.12 | uM | 13.53450 | 28.71380 | -0.9973 | -1.0000 | 1.4607 | 0.5367 | 0.9858 | 1.1139 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 5899.067 | uM | 0.02014 | 0.02724 | -0.9973 | -0.5462 | 2.4427 | 0.8474 | 0.9376 | 0.9897 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9120.001 | uM | 10.38820 | 12.94090 | -0.9973 | -1.0000 | 5.0000 | 0.2756 | 0.7682 | 0.6180 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9583.017 | uM | 0.29481 | 3.18710 | -0.9973 | -1.0000 | 0.4615 | 0.6194 | 0.8658 | 1.0456 | |
| BT-20 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 5904.095 | uM | 0.00177 | 0.00213 | -0.9973 | -0.7751 | 4.9993 | 1.3519 | 0.9867 | 0.6537 | |
| HCC70 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 14739.203 | uM | 0.00093 | 0.00145 | -0.9973 | -0.9997 | 2.4844 | 1.6705 | 0.9952 | 0.6862 | |
| SUM1315MO2 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 12428.165 | uM | 0.07880 | 1.06620 | -0.9973 | -1.0000 | 0.4217 | 0.6977 | 0.9477 | 0.7051 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7862.017 | uM | 0.34445 | 1.15410 | -0.9973 | -0.9467 | 0.8787 | 0.7815 | 0.9793 | 1.3198 | |
| Hs 578T | TNBC | Basal B | IKK16 | IKK | NFKB | 7472.1 | uM | 5.06940 | 6.31580 | -0.9972 | -0.9998 | 4.9971 | 0.3359 | 0.9967 | 1.1120 | |
| HCC1187 | TNBC | Basal A | Nelfinavir | 12696.174 | uM | 5.83210 | 8.5520 | -0.9972 | -1.0000 | 2.8701 | 0.3497 | 0.9263 | 0.6299 | |||
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7508.067 | uM | 0.02564 | 0.03092 | -0.9972 | -0.7743 | 5.0000 | 0.9845 | 0.9860 | 0.7560 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7532.098 | uM | 2.29380 | 3.63270 | -0.9972 | -1.0000 | 2.3895 | 0.5839 | 0.9418 | 0.6992 |