Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
SUM159PT	TNBC	Basal B	GW-5074		CRAF	MAPK	7531.088	uM	40.33110	43.51550	0.7440	-0.2311	4.9988	0.0100	0.8340	3.3184
SK-BR-3	HER2amp	Luminal	Purvalanol A		CDK1	CDK	7527.067	uM	inf	inf	0.9639	0.9639	0.0000	0.0101	0.4774	1.9179
MDA-MB-231	TNBC	Basal B	(Z)-4-Hydroxytamoxifen		ESR1		7892.016	uM	inf	inf	0.9547	0.9547	0.0000	0.0102	0.5298	2.3475
ZR-75-1	HR+	Luminal	Nilotinib		ABL	nRTK	12003.145	uM	inf	inf	0.9728	0.9728	0.0000	0.0104	0.0000	0.9611
MDA-MB-361	HER2amp	Luminal	PS-1145		IKK	NFKB	7508.065	uM	inf	inf	1.0103	1.0103	0.0000	0.0104	0.0000	0.7854
HCC1569	HER2amp	Basal A	PD184352		MEK	MAPK	12523.155	uM	inf	inf	0.9460	0.9460	0.0000	0.0104	0.1224	1.0583
HCC1569	HER2amp	Basal A	PD184352		MEK	MAPK	12523.155	uM	inf	inf	0.9460	0.9460	0.0000	0.0104	0.1224	1.0583
SUM159PT	TNBC	Basal B	Dichloroacetate		PDK	PDK	13004.176	uM	inf	0.07582	0.9422	0.9462	0.8257	0.0105	0.5981	3.4179
BT-20	TNBC	Basal A	Methotrexate		DHFR	Metabolism	5903.084	uM	inf	inf	1.0102	1.0102	0.0000	0.0105	0.0000	1.2088
Hs 578T	TNBC	Basal B	Nutlin 3a		MDM2	MDM2	7474.066	uM	inf	60.4740	0.7403	0.5492	3.1058	0.0106	0.8617	2.7948
HCC1569	HER2amp	Basal A	CPT-11		TOP1	TOP	7825.007	uM	inf	81.60280	0.8135	0.5446	3.6135	0.0106	0.5793	1.5199
BT-549	TNBC	Basal B	Lapatinib		EGFR/HER2	ErbB	5909.098	uM	inf	6.25710	0.8768	0.8207	0.8467	0.0108	0.6521	2.6253
SUM159PT	TNBC	Basal B		Cetuximab	EGFR	ErbB	7920.018	uM	inf	inf	0.9492	0.9492	0.0000	0.0108	0.4781	4.3723
SK-BR-3	HER2amp	Luminal	AG1024		IGF1R	RTK	7527.066	uM	inf	6.36410	0.8872	0.8872	4.9991	0.0109	0.6541	1.9970
T47DKBLUC	Unknown	Unknown	Purvalanol A		CDK1	CDK	7546.067	uM	inf	30.67960	0.7500	0.7500	4.9997	0.0111	0.8401	0.8509
HCC1569	HER2amp	Basal A	AS-252424		PI3K	PI3K	10872.153	uM	46.92640	45.54350	0.8250	0.0654	4.6895	0.0111	0.5771	1.5576
BT-20	TNBC	Basal A	AG1024		IGF1R	RTK	5903.066	uM	inf	8.69250	0.8579	0.8577	4.9852	0.0112	0.5851	1.1945
T47DKBLUC	Unknown	Unknown	GSK1838705A		IGF1R	RTK	7545.092	uM	inf	0.24280	0.9122	0.9282	4.6306	0.0113	0.6526	0.9794
MCF12A	NM	Basal B	SB-3CT		MMP2/9	MMP	10817.144	uM	inf	10.66090	0.9205	0.9198	4.9870	0.0113	0.6311	1.4640
SUM225CWN	HER2amp	Basal A	Methotrexate		DHFR	Metabolism	7534.084	uM	inf	inf	0.9557	0.9557	0.0000	0.0114	0.0130	0.8905
CAMA-1	HR+	Luminal	Gefitinib		EGFR	ErbB	7805.016	uM	30.78110	34.5910	0.3689	-0.3932	4.9723	0.0114	0.9712	1.2059
HCC1806	TNBC	Basal A	Dichloroacetate		PDK	PDK	12702.176	uM	inf	4.62970	0.9096	0.7552	1.6198	0.0114	0.8024	1.7142
MCF12A	NM	Basal B	Purvalanol A		CDK1	CDK	7490.067	uM	inf	inf	0.9463	0.9463	0.0000	0.0115	0.2333	2.6472
T47DKBLUC	Unknown	Unknown	Glycyl-H-1152		ROCK2		12608.169	uM	inf	inf	0.8859	0.8859	0.0000	0.0116	0.3497	1.2559
BT-549	TNBC	Basal B	GSK1838705A		IGF1R	RTK	5910.091	uM	inf	inf	0.9825	0.9825	0.0000	0.0118	0.2290	3.3208

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)