Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10264.011 | uM | 2.47060 | 23.53780 | -0.6543 | -0.9921 | 0.4850 | 0.5557 | 0.9929 | 1.3983 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 10264.024 | uM | 0.03199 | 0.04163 | -0.2424 | -0.2295 | 1.4346 | 0.7421 | 0.9942 | 1.2223 | |
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 10264.024 | uM | inf | 998.55080 | 0.6181 | -0.1985 | 0.2283 | 0.1218 | 0.6493 | 1.2223 | |
| LY2 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 10264.024 | uM | 25.92930 | 87.30260 | 0.4027 | -1.0000 | 0.9049 | 0.1136 | 0.6077 | 1.2223 | |
| LY2 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10264.026 | uM | inf | inf | 0.8544 | 0.8544 | 0.0000 | 0.0234 | 0.5438 | 1.5047 | |
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10264.026 | uM | 455.10120 | 1000.00000 | -0.7152 | -0.7162 | 1.1292 | 0.3424 | 0.7193 | 1.5047 | ||
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10264.026 | uM | inf | inf | 0.9706 | 0.9706 | 0.0000 | -0.0006 | 0.1039 | 1.5047 | |
| LY2 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 10264.037 | uM | 0.04940 | 0.06826 | -0.6530 | -0.3280 | 1.5602 | 0.7216 | 0.9558 | 1.3861 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 10264.121 | uM | 13.98020 | 36.9810 | -0.4963 | -1.0000 | 1.1294 | 0.2307 | 0.9667 | 1.3643 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 10264.121 | uM | 0.28155 | 1.02050 | -0.3709 | -0.5394 | 0.5683 | 0.5872 | 0.9712 | 1.3643 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10264.121 | uM | 0.19334 | 0.23702 | -0.8571 | -0.3147 | 2.3968 | 0.5984 | 0.8617 | 1.3643 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 10264.131 | uM | inf | inf | 0.2519 | 0.2519 | 0.0000 | 0.4839 | 0.4210 | 1.4548 | |
| LY2 | HR+ | Luminal | 5-FU | TYMS | TYMS | 10264.131 | uM | 45.54210 | 231.48110 | -0.5236 | -0.7162 | 0.5467 | 0.6044 | 0.9825 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10264.131 | uM | 6.67580 | 20.59690 | -0.6200 | -0.8300 | 0.8683 | 0.3839 | 0.9935 | 1.4548 | |
| MDA-MB-134-VI | HR+ | Luminal | Taxol | TUBB | TUBB | 10265.002 | uM | 0.00646 | 0.00934 | -0.3046 | -0.2811 | 1.2076 | 0.8329 | 0.9093 | 0.3365 | |
| MDA-MB-134-VI | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10265.002 | uM | 0.00770 | 0.01408 | -0.2837 | -0.2417 | 0.6532 | 0.6461 | 0.8540 | 0.3365 | |
| MDA-MB-134-VI | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | 248.53190 | 343.89760 | -0.9993 | -1.0000 | 3.3827 | 0.2219 | 0.9702 | 0.3095 | |
| MDA-MB-134-VI | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | 321.29740 | 424.13160 | -0.5912 | -0.9443 | 3.8202 | 0.2539 | 0.730 | 0.3095 | |
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | inf | inf | -0.7752 | -0.7752 | 0.0000 | 0.3146 | 0.5744 | 0.3095 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 10266.001 | uM | 0.01345 | 0.01380 | -0.1922 | -0.0242 | 1.8703 | 0.6598 | 0.8030 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 10266.001 | uM | 0.05908 | 0.06633 | -0.3222 | -0.1740 | 2.5780 | 0.5795 | 0.9469 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10266.001 | uM | 0.01358 | 0.01386 | -0.2223 | -0.0556 | 4.9998 | 0.6171 | 0.9643 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | Taxol | TUBB | TUBB | 10266.002 | uM | 0.01263 | 0.02198 | -0.6138 | -0.3854 | 1.0308 | 0.7789 | 0.9445 | 0.6757 | |
| MDA-MB-436 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10266.002 | uM | 0.00837 | 0.00966 | -0.2028 | -0.1558 | 1.8929 | 0.6382 | 0.9706 | 0.6757 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10266.011 | uM | 0.02860 | 0.03214 | -0.5466 | -0.3964 | 4.9995 | 0.9392 | 0.9813 | 0.6895 |