Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12379.152 | uM | 0.27085 | 0.33716 | -0.9958 | -0.9933 | 4.9966 | 0.6552 | 0.9985 | 0.5297 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7804.011 | uM | 47.18320 | 73.7730 | -0.7090 | -0.7287 | 2.0117 | 0.3853 | 0.9985 | 2.4113 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7821.017 | uM | 0.78388 | 0.97271 | -1.0000 | -0.9710 | 5.0000 | 0.7996 | 0.9985 | 0.3792 | |
| HCC1569 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7447.084 | uM | 49.56820 | 67.98270 | -0.9217 | -0.9241 | 3.3134 | 0.4033 | 0.9985 | 1.5152 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10150.012 | uM | 0.02042 | 0.02445 | -0.7512 | -0.7308 | 4.9997 | 1.1335 | 0.9985 | 0.4611 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5894.095 | uM | 0.46640 | 0.69919 | -0.9010 | -0.8976 | 2.5388 | 0.6159 | 0.9985 | 1.7133 | |
| SUM52PE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10695.152 | uM | 2.59830 | 4.10010 | -0.9330 | -0.9389 | 2.3173 | 0.5662 | 0.9985 | 1.2495 | |
| SUM1315MO2 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10875.145 | uM | 0.10386 | 0.19799 | -0.9918 | -0.9954 | 1.6979 | 0.8831 | 0.9985 | 0.7643 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5901.091 | uM | 19.04840 | 28.45990 | -0.8741 | -0.8850 | 2.5375 | 0.4460 | 0.9984 | 1.9229 | |
| SUM1315MO2 | TNBC | Basal B | Taxol | TUBB | TUBB | 9797.002 | uM | 0.00284 | 0.00504 | -0.9455 | -0.9308 | 1.8346 | 1.3072 | 0.9984 | 0.4052 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7436.065 | uM | 33.8530 | 69.90340 | -0.8645 | -0.8217 | 1.3406 | 0.5995 | 0.9984 | 1.2177 | |
| SK-BR-3 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9760.131 | uM | 2.20840 | 3.62970 | -0.9282 | -0.9079 | 2.0834 | 0.6047 | 0.9984 | 0.9878 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12400.17 | uM | 0.07474 | 0.11640 | -0.9170 | -0.9300 | 2.3720 | 0.9712 | 0.9984 | 1.1992 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9146.002 | uM | 0.00498 | 0.00636 | -0.6733 | -0.6767 | 3.4844 | 0.9399 | 0.9984 | 1.2611 | |
| LY2 | HR+ | Luminal | Nelfinavir | 12627.174 | uM | 8.39840 | 12.76790 | -0.8520 | -1.0000 | 2.6227 | 0.1651 | 0.9984 | 1.3419 | |||
| MCF 10A | NM | Basal B | AG1478 | EGFR | ErbB | 7870.016 | uM | 0.26376 | 0.28837 | -0.1465 | -0.1417 | 2.7964 | 0.5610 | 0.9984 | 2.1045 | |
| MDA-MB-361 | HER2amp | Luminal | Bosutinib | Src | nRTK | 12379.17 | uM | 1.26110 | 1.5010 | -0.6583 | -0.6497 | 4.7811 | 0.3770 | 0.9984 | 0.5805 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 7486.098 | uM | 0.78463 | 1.45630 | -0.8091 | -0.8272 | 1.5786 | 0.5257 | 0.9984 | 0.9165 | |
| SUM149PT | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7530.067 | uM | 3.08050 | 5.95540 | -0.8631 | -0.9013 | 1.5633 | 0.4944 | 0.9984 | 2.0748 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9759.002 | uM | 0.01110 | 0.01416 | -0.6775 | -0.6538 | 3.4304 | 0.9680 | 0.9984 | 1.1336 | |
| HCC3153 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14131.189 | uM | 0.44518 | 0.71071 | -0.9115 | -0.9112 | 2.2180 | 0.6899 | 0.9984 | 1.2288 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7477.084 | uM | 0.00794 | 0.01777 | -0.9982 | -1.0000 | 1.3641 | 1.1602 | 0.9984 | 0.9476 | |
| MCF 10F | NM | - | Bortezomib | Proteasome | Proteasome | 7487.074 | uM | 0.14698 | 0.69853 | -0.9095 | -0.9810 | 0.6967 | 0.8500 | 0.9984 | 1.4197 | |
| 600MPE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12224.16 | uM | 8.18440 | 11.67550 | -0.5754 | -0.6951 | 2.4529 | 0.1352 | 0.9984 | 0.7734 |