Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 5895.098 | uM | 1.84620 | 1.07940 | 0.2337 | 0.4659 | 5.0000 | 0.0845 | 0.8011 | 1.4041 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12224.152 | uM | 3.0690 | 3.80580 | -0.9666 | -0.9662 | 5.0000 | 0.6239 | 0.9973 | 1.0761 | |
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| 184B5 | NM | Basal | 2-deoxyglucose | 12979.177 | uM | 559.39550 | 583.2410 | -0.1158 | -0.1161 | 5.0000 | 0.2148 | 0.7107 | 0.5647 | |||
| 21NT | HER2amp | - | MG-132 | Proteasome | Proteasome | 14194.189 | uM | 0.10310 | 0.10891 | -0.3512 | -0.1578 | 5.0000 | 0.6651 | 0.5943 | 2.3616 | |
| AU565 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9146.122 | uM | inf | 0.00184 | 0.5003 | 0.6442 | 5.0000 | 0.2137 | 0.8848 | 1.3408 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10880.155 | uM | 0.27813 | 0.23011 | 0.5266 | 0.3062 | 5.0000 | 0.3052 | 0.6953 | 1.5205 | |
| 600MPE | HR+ | Luminal | IKK16 | IKK | NFKB | 5898.093 | uM | 4.19220 | 5.22240 | -0.9978 | -1.0000 | 5.0000 | 0.4738 | 0.9724 | 0.6963 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5901.067 | uM | inf | 7.55960 | 0.5017 | 0.5670 | 5.0000 | 0.1061 | 0.9459 | 1.8762 | |
| 184A1 | NM | Basal | Mebendazole | 12684.174 | uM | inf | 0.36667 | 0.5334 | 0.5745 | 5.0000 | 0.1723 | 0.9699 | 1.4645 | |||
| 184B5 | NM | Basal | CGC-11047 | Polyamine analogue | 9095.026 | uM | 486.65450 | 602.90190 | -0.9562 | -0.9592 | 5.0000 | 0.3089 | 0.9969 | 1.0168 | ||
| 600MPE | HR+ | Luminal | Bosutinib | Src | nRTK | 12224.145 | uM | 6.17790 | 4.29030 | 0.3962 | 0.4192 | 5.0000 | 0.1266 | 0.9757 | 0.9737 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 12979.177 | uM | 0.02740 | 0.03413 | -1.0000 | -1.0000 | 5.0000 | 1.0789 | 0.9988 | 0.5647 | |
| AU565 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7794.016 | uM | 10.77660 | 7.89410 | 0.0679 | 0.3945 | 5.0000 | 0.1625 | 0.6985 | 1.9541 | ||
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.091 | uM | 1.70110 | 1.39940 | 0.2219 | 0.3117 | 5.0000 | 0.2329 | 0.7603 | 1.9229 | |
| 184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 7787.018 | uM | 839.83530 | 1000.00000 | -0.8398 | -0.6967 | 5.0000 | 0.2577 | 0.8874 | 0.3791 | ||
| 21NT | HER2amp | - | Mebendazole | 13575.174 | uM | 0.70544 | 0.60467 | 0.2760 | 0.2687 | 5.0000 | 0.2944 | 0.9408 | 1.5845 | |||
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 9118.019 | uM | inf | 1.05170 | 0.7726 | 0.8575 | 5.0000 | 0.0428 | 0.5984 | 1.0707 | |
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7794.018 | uM | 903.45840 | 1000.00000 | -0.5938 | -0.3307 | 5.0000 | 0.0895 | 0.8461 | 1.6812 | ||
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9120.021 | uM | 44.1310 | 54.28280 | -0.9070 | -0.9079 | 5.0000 | 0.2126 | 0.9946 | 0.6486 | |
| 184A1 | NM | Basal | TAPI-0 | TACE/Collagenase | 5895.096 | uM | inf | 6.62580 | 0.8804 | 0.8803 | 5.0000 | -0.0065 | 0.5959 | 1.4232 | ||
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 5894.066 | uM | 0.20895 | 0.19857 | 0.0442 | 0.1124 | 5.0000 | 0.3444 | 0.9895 | 1.5027 | |
| 600MPE | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9118.017 | uM | 0.31034 | 0.33301 | -0.1712 | -0.2113 | 5.0000 | 0.5870 | 0.9550 | 1.0401 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5904.067 | uM | 12.39380 | 15.43930 | -0.9979 | -1.0000 | 5.0000 | 0.3909 | 0.9919 | 1.0398 | |
| BT-20 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5903.084 | uM | 64.21230 | 73.43050 | -0.5323 | -0.4778 | 5.0000 | 0.3012 | 0.9916 | 1.2088 |