Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 10880.156 | uM | 0.57383 | 7.51240 | -0.8788 | -1.0000 | 0.4272 | 0.4508 | 0.8269 | 1.5288 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5900.085 | uM | 0.22253 | 0.56950 | -0.7376 | -0.7889 | 1.0076 | 0.5715 | 0.9983 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5901.084 | uM | 0.08674 | 0.20069 | -0.9407 | -0.9232 | 1.2470 | 0.7548 | 0.9992 | 1.7402 | |
| AU565 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10880.149 | uM | inf | inf | 0.8678 | 0.8678 | 0.0000 | 0.0766 | 0.1343 | 1.6289 | |
| AU565 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10880.154 | uM | inf | inf | 0.9251 | 0.9251 | 0.0000 | 0.0449 | -0.1660 | 1.7853 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9146.049 | uM | 0.27923 | 2.3090 | -0.7753 | -1.0000 | 0.5201 | 0.5661 | 0.8221 | 1.1054 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7793.016 | uM | 0.65307 | 1.61880 | -0.6853 | -0.7468 | 1.0066 | 0.4341 | 0.9920 | 1.1616 | |
| AU565 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7794.016 | uM | 2.89250 | 6.50790 | -0.1897 | -0.4920 | 0.8449 | 0.2166 | 0.9973 | 1.9541 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9146.049 | uM | 0.02540 | 0.02197 | 0.0494 | 0.1134 | 1.7740 | 0.6433 | 0.7645 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 7793.012 | uM | 0.05955 | 0.07345 | -0.2301 | -0.1774 | 1.4481 | 0.6528 | 0.9875 | 1.1030 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9146.12 | uM | 0.01172 | 0.01476 | -0.6973 | -0.6633 | 3.6621 | 1.1143 | 0.9852 | 1.1135 | |
| AU565 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7793.011 | uM | 0.01320 | 0.01840 | -0.7052 | -0.6394 | 2.4793 | 1.1485 | 0.9950 | 1.1456 | |
| AU565 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10880.15 | uM | 9.07190 | 75.67630 | 0.2009 | -1.0000 | 0.5179 | 0.1669 | 0.9797 | 1.5829 | ||
| AU565 | HER2amp | Luminal | GM6001 | MMP | MMP | 5900.096 | uM | inf | inf | 0.9215 | 0.9215 | 0.0000 | 0.0442 | 0.2561 | 2.7795 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9146.001 | uM | 2.55360 | 9.30180 | -0.6291 | -1.0000 | 0.8499 | 0.3663 | 0.8348 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9035.001 | uM | 3.31290 | 213.70830 | 0.1236 | -1.0000 | 0.2637 | 0.2641 | 0.8354 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7793.001 | uM | 5.6020 | 10.09590 | -0.8129 | -1.0000 | 1.8652 | 0.2425 | 0.9715 | 1.1508 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.091 | uM | 1.70110 | 1.39940 | 0.2219 | 0.3117 | 5.0000 | 0.2329 | 0.7603 | 1.9229 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.07 | uM | 9.99730 | 1.73580 | 0.3924 | 0.4038 | 0.9414 | 0.1792 | 0.9569 | 1.9178 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5900.092 | uM | 3.64180 | 4.75470 | -0.5748 | -0.5782 | 2.8816 | 0.3267 | 0.9980 | 2.6334 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5900.098 | uM | 1.68930 | 2.73370 | -0.8099 | -0.7858 | 1.9622 | 0.4216 | 0.9981 | 2.2937 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.098 | uM | 2.47210 | 4.04280 | -0.8645 | -0.8719 | 2.0519 | 0.4223 | 0.9988 | 1.8013 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9035.001 | uM | 0.00071 | 0.00076 | 0.2153 | -0.1767 | 5.0000 | 0.9858 | 0.7915 | 2.4291 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9146.001 | uM | 0.01119 | 0.01274 | -0.9678 | -0.4577 | 5.0000 | 0.8676 | 0.8304 | 1.2878 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7793.001 | uM | 0.01232 | 0.01448 | -0.9105 | -0.6208 | 5.0000 | 0.9168 | 0.9189 | 1.1508 |