Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 11854.144 | uM | 37.65360 | 91.22140 | -0.0581 | -0.9998 | 1.2414 | 0.1163 | 0.9803 | 1.3102 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11854.155 | uM | inf | inf | 0.9135 | 0.9135 | 0.0000 | 0.0714 | 0.3056 | 1.3396 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10581.146 | uM | inf | 0.26070 | 0.6711 | 0.6013 | 0.2749 | 0.1785 | 0.8230 | 1.1650 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10581.141 | uM | 5.68520 | 11.73980 | -0.9996 | -1.0000 | 1.5151 | 0.3224 | 0.9843 | 0.6310 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 11854.158 | uM | 11.36580 | 18.74490 | -0.9093 | -1.0000 | 2.1958 | 0.2543 | 0.9867 | 1.3776 | |
| BT-20 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 5903.068 | uM | 0.48382 | 7.10270 | 0.1688 | -0.2619 | 0.1568 | 0.4931 | 0.80 | 1.0852 | |
| BT-20 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 5902.069 | uM | 0.01812 | 0.00360 | 0.3853 | 0.4292 | 1.2090 | 0.4011 | 0.9938 | 1.1199 | |
| BT-20 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5902.084 | uM | 40.15030 | 34.97670 | -0.1078 | 0.2491 | 4.9999 | 0.2457 | 0.7374 | 1.3532 | |
| BT-20 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5903.084 | uM | 64.21230 | 73.43050 | -0.5323 | -0.4778 | 5.0000 | 0.3012 | 0.9916 | 1.2088 | |
| BT-20 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5904.085 | uM | 80.33360 | 132.40540 | -0.5736 | -0.8316 | 1.9603 | 0.1452 | 0.9935 | 1.2247 | |
| BT-20 | TNBC | Basal A | Sulindac sulfide | COX1/2 | COX | 10581.136 | uM | inf | inf | 0.3918 | 0.3918 | 0.0000 | 0.1575 | 0.4199 | 0.8342 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5904.067 | uM | 12.39380 | 15.43930 | -0.9979 | -1.0000 | 5.0000 | 0.3909 | 0.9919 | 1.0398 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5902.067 | uM | 13.20150 | 16.4310 | -0.9807 | -0.9934 | 5.0000 | 0.3462 | 0.9959 | 1.1750 | |
| BT-20 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5903.067 | uM | 8.58980 | 11.8170 | -0.9924 | -0.9940 | 3.4316 | 0.4190 | 0.9975 | 1.2584 | |
| BT-20 | TNBC | Basal A | TAPI-0 | TACE/Collagenase | 5904.096 | uM | 5.5530 | 4.6180 | 0.1678 | 0.1053 | 1.2823 | 0.1147 | 0.9829 | 0.9724 | ||
| BT-20 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10581.14 | uM | 2.03750 | 3.03650 | -0.7465 | -0.7552 | 2.3072 | 0.4218 | 0.9643 | 0.9569 | |
| BT-20 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 11854.159 | uM | 1.33180 | 2.33360 | -0.7274 | -0.7348 | 1.6117 | 0.3447 | 0.9957 | 1.2639 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10581.135 | uM | inf | inf | 0.8250 | 0.8250 | 0.0000 | 0.0663 | 0.1975 | 0.4426 | |
| BT-20 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 11854.135 | uM | inf | inf | 0.8384 | 0.8384 | 0.0000 | 0.0710 | 0.5319 | 1.3170 | |
| BT-20 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 10581.144 | uM | inf | inf | -0.8452 | -0.8452 | 0.0000 | 0.6833 | 0.5657 | 1.2048 | |
| BT-20 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 11854.144 | uM | 0.22984 | 19.90090 | -0.7186 | -1.0000 | 0.2463 | 0.5542 | 0.7183 | 1.3102 | |
| BT-20 | TNBC | Basal A | Torkinib | 15385.211 | uM | 0.00007 | 0.00943 | -0.7410 | -0.9904 | 0.2213 | 1.1960 | 0.990 | 0.7321 | |||
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10581.138 | uM | 2.27850 | 21.40780 | -0.6125 | -1.0000 | 0.4904 | 0.4054 | 0.8601 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11854.16 | uM | inf | 0.18692 | 0.5222 | 0.5463 | 1.7992 | 0.1850 | 0.9584 | 1.3102 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 5904.1 | uM | inf | 1.14280 | 0.3721 | 0.5219 | 5.0000 | 0.2002 | 0.7071 | 1.3369 |