Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 10385.093 | uM | 1.07920 | 1.19010 | -0.2709 | -0.1136 | 2.0927 | 0.3735 | 0.9432 | 0.6082 | |
| BT-20 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 5903.102 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0171 | -0.1575 | 1.2557 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 10385.065 | uM | 0.36381 | 5.4850 | -0.9923 | -1.0000 | 0.4049 | 1.1403 | 0.6735 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5902.065 | uM | 17.56130 | 31.77990 | -0.8086 | -0.7969 | 1.6069 | 0.7464 | 0.9898 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5904.065 | uM | 9.90230 | 15.89510 | -0.8823 | -0.8820 | 2.1482 | 0.8658 | 0.9964 | 1.1681 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5904.074 | uM | 0.56544 | 0.77026 | -0.2190 | -0.1688 | 0.9408 | 0.3518 | 0.9569 | 0.9654 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5903.074 | uM | 1.02210 | 3.13290 | -0.3635 | -0.6039 | 0.7071 | 0.3330 | 0.9862 | 1.0729 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5902.074 | uM | 1.97260 | 8.09640 | -0.2309 | -0.7316 | 0.6384 | 0.2588 | 0.9950 | 1.2939 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 11854.143 | uM | 4070.77010 | 999.99960 | 0.0729 | 0.4181 | 1.2888 | 0.0724 | 0.5939 | 1.1185 | |
| BT-20 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 10581.143 | uM | 462.67510 | 1000.00000 | -0.9347 | -0.4771 | 0.8693 | 0.3413 | 0.6471 | 0.9062 | |
| BT-20 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 10385.065 | uM | 179.6170 | 343.96450 | -0.9882 | -0.9880 | 1.6785 | 0.7627 | 0.8498 | 0.6599 | |
| BT-20 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 5902.065 | uM | 243.46030 | 576.57230 | -0.7163 | -0.7840 | 1.0939 | 0.5225 | 0.9881 | 1.2690 | |
| BT-20 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 5904.065 | uM | 124.97640 | 292.94750 | -0.9078 | -0.9293 | 1.2330 | 0.6450 | 0.9961 | 1.1681 | |
| BT-20 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 11854.157 | uM | 6.14030 | 3.41560 | 0.1900 | 0.3493 | 2.0444 | 0.2292 | 0.8682 | 1.4808 | |
| BT-20 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10581.139 | uM | 4.11660 | 3.49190 | 0.0931 | 0.1489 | 2.1488 | 0.2879 | 0.9502 | 1.1488 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14116.189 | uM | 0.11656 | 0.17087 | -0.9997 | -1.0000 | 2.8722 | 1.1707 | 0.7408 | 0.5416 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14230.189 | uM | 0.27401 | 0.47494 | -1.0000 | -1.0000 | 1.9974 | 0.7978 | 0.9974 | 0.4635 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 11854.16 | uM | 7.8450 | 6.64530 | 0.3364 | 0.0291 | 0.3615 | 0.2804 | 0.8971 | 1.3102 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10581.138 | uM | 5.16160 | 30.74760 | -0.4765 | -1.0000 | 0.6156 | 0.3418 | 0.9196 | 0.9462 | |
| BT-474 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7797.016 | uM | 0.25036 | 0.02995 | 0.2168 | 0.2584 | 0.3426 | 0.4729 | 0.9352 | 0.5155 | ||
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9158.037 | uM | 0.01213 | 0.01343 | -0.1754 | -0.3299 | 4.9817 | 0.9735 | 0.6470 | 0.4702 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9163.037 | uM | 0.02296 | 0.02797 | -0.9651 | -0.8419 | 4.9994 | 1.1656 | 0.9949 | 0.5258 | |
| BT-474 | HER2amp | Luminal | 2-deoxyglucose | 13125.177 | uM | inf | inf | -0.1564 | -0.1564 | 0.0000 | 0.4335 | 0.4985 | 0.8991 | |||
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12178.143 | uM | 1053.93470 | 690.84680 | 0.2785 | 0.1751 | 1.0203 | 0.1699 | 0.9078 | 0.7617 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12056.143 | uM | 322.2530 | 1000.00000 | 0.0366 | -0.3258 | 0.4431 | 0.2795 | 0.9185 | 1.0075 |