Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5897.085 | uM | 1.52970 | 2.52550 | -0.9132 | -0.8317 | 1.9539 | 0.6859 | 0.9971 | 1.2392 | |
| 184B5 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5896.067 | uM | 4.54790 | 8.20140 | -0.9586 | -1.0000 | 1.8632 | 0.4683 | 0.9969 | 1.4536 | |
| 184B5 | NM | Basal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5897.067 | uM | 7.12490 | 9.50480 | -0.9660 | -0.9702 | 3.7422 | 0.4265 | 0.9982 | 1.1908 | |
| 184B5 | NM | Basal | TAPI-0 | TACE/Collagenase | 5897.096 | uM | inf | 992.95260 | 0.8920 | 0.4929 | 0.4192 | 0.0203 | 0.7286 | 1.2810 | ||
| 184B5 | NM | Basal | Taxol | TUBB | TUBB | 12979.002 | uM | inf | 0.00871 | 0.5987 | 0.6417 | 4.9974 | 0.2293 | 0.6910 | 1.3178 | |
| 184B5 | NM | Basal | Taxol | TUBB | TUBB | 9095.002 | uM | 0.01783 | 0.01144 | -0.0925 | 0.1784 | 0.9939 | 0.4787 | 0.9002 | 1.0607 | |
| 184B5 | NM | Basal | TCS 2312 | CHK1 | CHK | 12566.152 | uM | 0.47856 | 0.67095 | -0.6926 | -0.4982 | 2.0460 | 0.4394 | 0.9768 | 1.4827 | |
| 184B5 | NM | Basal | TCS PIM-1 1 | Pim kinase | PIM | 12566.135 | uM | 2.28850 | 2.41580 | -0.0883 | -0.0683 | 2.3643 | 0.3297 | 0.9954 | 1.6384 | |
| 184B5 | NM | Basal | Temsirolimus | MTOR | MTOR | 12566.168 | uM | 31.79770 | 47.19180 | -0.9110 | -1.0000 | 2.7825 | 0.3358 | 0.8544 | 1.4366 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 9095.121 | uM | 0.07632 | 0.71426 | -0.8323 | -1.0000 | 0.4913 | 0.8207 | 0.9828 | 1.1992 | |
| 184B5 | NM | Basal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12566.169 | uM | 2.34370 | 11.34480 | -0.7494 | -1.0000 | 0.6966 | 0.3916 | 0.9813 | 1.6359 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 5897.093 | uM | 13.34050 | 4.19070 | 0.4757 | 0.4767 | 2.6493 | 0.0943 | 0.9817 | 1.2047 | |
| 184B5 | NM | Basal | Trastuzumab | HER2 | ErbB | 9095.026 | uM | inf | 6.71320 | 0.7144 | 0.5130 | 4.9565 | -0.0290 | 0.80 | 1.0168 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 5897.065 | uM | 88.76350 | 175.5770 | -0.9241 | -0.9748 | 1.5858 | 0.5421 | 0.9958 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 5896.065 | uM | 26.14030 | 64.67810 | -0.8868 | -0.9295 | 1.1596 | 0.6633 | 0.9990 | 1.4978 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5897.074 | uM | 0.14593 | 0.26720 | -0.6810 | -0.6218 | 1.3360 | 0.6294 | 0.9925 | 1.2824 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5896.074 | uM | 0.08583 | 0.37083 | -0.6648 | -0.7348 | 0.6178 | 0.6095 | 0.9963 | 1.4124 | |
| 184B5 | NM | Basal | Valproic acid | HDAC | HDAC | 12566.143 | uM | 826.74090 | 1000.00000 | 0.0037 | -0.0768 | 0.7513 | 0.2545 | 0.9630 | 1.6413 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 5896.065 | uM | 114.54920 | 884.06290 | -0.8093 | -1.0000 | 0.5376 | 0.5272 | 0.9847 | 1.4978 | |
| 184B5 | NM | Basal | Vorinostat | HDAC | HDAC | 5897.065 | uM | 217.22220 | 1000.00000 | -0.7078 | -0.8643 | 0.6574 | 0.4634 | 0.9850 | 1.2996 | |
| 184B5 | NM | Basal | XRP44X | ELK3 | MAPK | 12566.171 | uM | 0.34734 | 0.19490 | 0.1674 | 0.1823 | 0.7846 | 0.4183 | 0.9903 | 1.5151 | |
| 184B5 | NM | Basal | ZM-447439 | AURK | AURK | 12566.169 | uM | inf | 0.69572 | 0.6262 | 0.6434 | 1.3748 | 0.1369 | 0.9197 | 1.6359 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 |