Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7512.074 | 0.7553 | 0.4652 | 0.9022 | |
| MDA-MB-415 | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7512.074 | 0.5951 | 0.1252 | 0.9022 | |
| MDA-MB-415 | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7512.074 | 0.5709 | 0.0745 | 0.9022 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7517.074 | 0.9127 | 0.8844 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7517.074 | 0.9348 | 0.9140 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7517.074 | 0.9490 | 0.9329 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7517.074 | 0.8984 | 0.8650 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7517.074 | 0.8925 | 0.8570 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7517.074 | 0.7591 | 0.6710 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7517.074 | 0.4931 | 0.2613 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7517.074 | 0.3499 | 0.0085 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7517.074 | 0.2823 | -0.1234 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7518.074 | 0.8920 | 0.8639 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7518.074 | 0.9498 | 0.9375 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7518.074 | 0.8992 | 0.8730 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7518.074 | 0.9204 | 0.9002 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7518.074 | 0.8348 | 0.7891 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7518.074 | 0.7451 | 0.6679 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7518.074 | 0.5421 | 0.3707 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7518.074 | 0.3791 | 0.0991 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7518.074 | 0.3342 | 0.0169 | 1.6204 | |
| MX1 | Unknown | Unknown | Etoposide | TOP2 | TOP | 0.000853 | uM | 7523.074 | 0.9467 | 0.8752 | 0.8505 | |
| MX1 | Unknown | Unknown | Etoposide | TOP2 | TOP | 0.00427 | uM | 7523.074 | 0.9284 | 0.8327 | 0.8505 | |
| MX1 | Unknown | Unknown | Etoposide | TOP2 | TOP | 0.0213 | uM | 7523.074 | 0.9666 | 0.9217 | 0.8505 | |
| MX1 | Unknown | Unknown | Etoposide | TOP2 | TOP | 0.107 | uM | 7523.074 | 0.9313 | 0.8394 | 0.8505 |