Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 2.67 | uM | 7555.091 | 0.9852 | 0.9815 | 1.6040 | |
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 13.3 | uM | 7555.091 | 0.9643 | 0.9551 | 1.6040 | |
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 66.7 | uM | 7555.091 | 0.8382 | 0.7916 | 1.6040 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5894.074 | 1.0061 | 1.0084 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5894.074 | 0.9700 | 0.9586 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5894.074 | 1.0482 | 1.0659 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.107 | uM | 5894.074 | 0.9455 | 0.9243 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.533 | uM | 5894.074 | 0.8547 | 0.7953 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 2.67 | uM | 5894.074 | 0.7822 | 0.6892 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 13.3 | uM | 5894.074 | 0.6644 | 0.5098 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 66.7 | uM | 5894.074 | 0.2251 | -0.2829 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 333 | uM | 5894.074 | 0.0436 | -0.7680 | 1.4541 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5895.074 | 1.0827 | 1.1468 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5895.074 | 1.0237 | 1.0422 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5895.074 | 1.0230 | 1.0410 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.107 | uM | 5895.074 | 0.9022 | 0.8246 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 0.533 | uM | 5895.074 | 0.9500 | 0.9105 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 2.67 | uM | 5895.074 | 0.8512 | 0.7323 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 13.3 | uM | 5895.074 | 0.7101 | 0.4740 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 66.7 | uM | 5895.074 | 0.3839 | -0.1481 | 1.1218 | |
| 184A1 | NM | Basal | Etoposide | TOP2 | TOP | 333 | uM | 5895.074 | 0.1016 | -0.7395 | 1.1218 | |
| 184B5 | NM | Basal | Etoposide | TOP2 | TOP | 0.000853 | uM | 5896.074 | 0.9905 | 0.9865 | 1.4124 | |
| 184B5 | NM | Basal | Etoposide | TOP2 | TOP | 0.00427 | uM | 5896.074 | 0.9590 | 0.9416 | 1.4124 | |
| 184B5 | NM | Basal | Etoposide | TOP2 | TOP | 0.0213 | uM | 5896.074 | 0.9451 | 0.9217 | 1.4124 | |
| 184B5 | NM | Basal | Etoposide | TOP2 | TOP | 0.107 | uM | 5896.074 | 0.8463 | 0.7771 | 1.4124 |