Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9045.05 | 0.1790 | -0.7728 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9045.05 | 0.1771 | -0.7758 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9045.05 | 0.3333 | -0.5013 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9045.05 | 0.0348 | -0.9714 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9953.037 | 1.0489 | 1.2053 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9953.037 | 1.2160 | 1.9851 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9953.037 | 0.9229 | 0.6970 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9953.037 | 0.5830 | -0.3375 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9953.037 | 0.2054 | -0.9217 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9953.037 | 0.1818 | -0.9390 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9953.037 | 0.1688 | -0.9477 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9953.037 | 0.2528 | -0.8803 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9953.037 | 0.0337 | -0.9981 | 0.4884 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7931.04 | 1.0824 | 1.1277 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7931.04 | 1.0158 | 1.0247 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7931.04 | 1.0853 | 1.1322 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7931.04 | 1.0293 | 1.0457 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7931.04 | 0.6938 | 0.5027 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7931.04 | 0.4462 | 0.0642 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7931.04 | 0.4302 | 0.0343 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7931.04 | 0.4673 | 0.1033 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7931.04 | 0.2582 | -0.3062 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7932.05 | 1.0356 | 1.0803 | 0.8883 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7932.05 | 1.0714 | 1.1614 | 0.8883 | |
| ZR-75-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7932.05 | 1.0063 | 1.0141 | 0.8883 |