Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 7433.066 | 1.0888 | 1.1647 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 7433.066 | 1.0003 | 1.0005 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 7433.066 | 1.0556 | 1.1032 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 7433.066 | 0.9925 | 0.9860 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7433.066 | 1.0078 | 1.0145 | 1.0755 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 7433.066 | 0.8868 | 0.7887 | 1.0755 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7435.066 | 0.9724 | 0.9383 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7435.066 | 0.8847 | 0.7434 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7435.066 | 1.0660 | 1.1486 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7435.066 | 0.9513 | 0.8913 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7435.066 | 1.0436 | 1.0981 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7435.066 | 0.9797 | 0.9546 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7435.066 | 0.9291 | 0.8418 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7435.066 | 1.0143 | 1.0320 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7435.066 | 0.9489 | 0.8858 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7436.066 | 1.0480 | 1.0749 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7436.066 | 0.9188 | 0.8714 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7436.066 | 1.0166 | 1.0260 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7436.066 | 0.9906 | 0.9853 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7436.066 | 0.9609 | 0.9383 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7436.066 | 0.9586 | 0.9347 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7436.066 | 0.9797 | 0.9680 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7436.066 | 0.8222 | 0.7151 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7436.066 | 0.7446 | 0.5866 | 1.2738 | |
| HCC1419 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7437.066 | 1.0509 | 1.3025 | 0.3525 |