Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 0.011 | uM | 9566.017 | 1.0102 | 1.0094 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 0.0552 | uM | 9566.017 | 0.9422 | 0.9460 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 0.276 | uM | 9566.017 | 0.7362 | 0.7371 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 1.38 | uM | 9566.017 | 0.1667 | -0.1229 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 6.9 | uM | 9566.017 | 0.0170 | -0.6931 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 34.5 | uM | 9566.017 | 0.0153 | -0.7081 | 2.1734 | |
| MCF 10F | NM | - | Epirubicin | TOP2 | TOP | 172 | uM | 9566.017 | 0.0022 | -0.8799 | 2.1734 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7873.017 | 0.9745 | 0.9767 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7873.017 | 1.0126 | 1.0114 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 0.011 | uM | 7873.017 | 0.8810 | 0.8884 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7873.017 | 0.4908 | 0.4488 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 0.276 | uM | 7873.017 | 0.3768 | 0.2853 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 1.38 | uM | 7873.017 | 0.0074 | -0.7835 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 6.9 | uM | 7873.017 | 0.0110 | -0.7405 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 34.5 | uM | 7873.017 | 0.0084 | -0.7710 | 2.2073 | |
| MCF12A | NM | Basal B | Epirubicin | TOP2 | TOP | 172 | uM | 7873.017 | 0.0049 | -0.8205 | 2.2073 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.000441 | uM | 7875.017 | 0.9146 | 0.8922 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.00221 | uM | 7875.017 | 1.0226 | 1.0280 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.011 | uM | 7875.017 | 0.9946 | 0.9933 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.0552 | uM | 7875.017 | 0.9820 | 0.9776 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 0.276 | uM | 7875.017 | 0.8026 | 0.7448 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 1.38 | uM | 7875.017 | 0.2064 | -0.2491 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 6.9 | uM | 7875.017 | 0.2810 | -0.0905 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 34.5 | uM | 7875.017 | 0.2207 | -0.2172 | 1.6110 | |
| MCF7 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 172 | uM | 7875.017 | 0.0003 | -0.9878 | 1.6110 |