Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 7538.078 | 0.9639 | 0.9175 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 7538.078 | 0.7909 | 0.5290 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 7538.078 | 0.5198 | -0.0544 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 7538.078 | 0.2627 | -0.5671 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 7538.078 | 0.2648 | -0.5632 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 7538.078 | 0.0004 | -0.9998 | 0.8734 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 7540.078 | 1.0013 | 1.0027 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 7540.078 | 1.1347 | 1.2838 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 7540.078 | 1.0183 | 1.0384 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 7540.078 | 0.9986 | 0.9971 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 7540.078 | 0.6588 | 0.2904 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 7540.078 | 0.0984 | -0.8248 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 7540.078 | 0.1349 | -0.7560 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 7540.078 | 0.1454 | -0.7359 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 7540.078 | 0.0003 | -0.9997 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 9889.034 | 1.0310 | 1.0449 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 9889.034 | 0.9992 | 0.9988 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 9889.034 | 1.0178 | 1.0258 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 9889.034 | 0.9104 | 0.8679 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 9889.034 | 0.5202 | 0.2431 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 9889.034 | 0.2044 | -0.3700 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 9889.034 | 0.1909 | -0.4006 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 9889.034 | 0.2378 | -0.2967 | 1.3742 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9889.034 | 0.0187 | -0.8893 | 1.3742 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 9897.034 | 1.0361 | 1.1881 | 0.3940 |