Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 9897.034 | 1.0218 | 1.1125 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 9897.034 | 1.0098 | 1.0501 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 9897.034 | 0.8673 | 0.3936 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 9897.034 | 0.6793 | -0.2503 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 9897.034 | 0.2165 | -0.9588 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 9897.034 | 0.4957 | -0.6630 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 9897.034 | 0.4960 | -0.6625 | 0.3940 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9897.034 | 0.0458 | -0.9992 | 0.3940 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 7926.077 | 1.1088 | 1.2698 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 7926.077 | 0.9770 | 0.9439 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 7926.077 | 1.0320 | 1.0788 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 7926.077 | 0.9155 | 0.7950 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 7926.077 | 0.7953 | 0.5106 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 7926.077 | 0.4101 | -0.3291 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 7926.077 | 0.2939 | -0.5540 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 7926.077 | 0.3852 | -0.3788 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 7926.077 | 0.0961 | -0.8866 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 10150.034 | 1.0640 | 1.3770 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 10150.034 | 0.9931 | 0.9618 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 10150.034 | 1.0770 | 1.4590 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 10150.034 | 0.9788 | 0.8843 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 10150.034 | 0.7893 | 0.0350 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 10150.034 | 0.4450 | -0.7901 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 10150.034 | 0.0897 | -0.9976 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 10150.034 | 0.0899 | -0.9976 | 0.3592 |