Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9386.121 | 0.1266 | -0.6566 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9386.121 | 0.0738 | -0.7834 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 92 | uM | 9386.121 | 0.0127 | -0.9518 | 1.1728 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 7841.077 | 0.9855 | 0.9357 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 7841.077 | 0.9780 | 0.9030 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 7841.077 | 0.9326 | 0.7113 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 7841.077 | 0.9363 | 0.7265 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 7841.077 | 0.9375 | 0.7312 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 7841.077 | 0.6265 | -0.2969 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 7841.077 | 0.2372 | -0.9198 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 7841.077 | 0.1462 | -0.9728 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 7841.077 | 0.0126 | -0.9999 | 0.4474 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7849.007 | 1.0395 | 1.1860 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7849.007 | 0.9705 | 0.8671 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7849.007 | 0.9726 | 0.8765 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7849.007 | 0.9460 | 0.7604 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 7849.007 | 0.9221 | 0.6599 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 7849.007 | 0.6388 | -0.2855 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 7849.007 | 0.5675 | -0.4556 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 7849.007 | 0.5356 | -0.5234 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7849.007 | 0.5203 | -0.5541 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7849.043 | 1.0519 | 1.3106 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7849.043 | 0.9498 | 0.7264 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7849.043 | 0.9715 | 0.8416 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7849.043 | 0.9925 | 0.9574 | 0.3502 |