Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7897.037 | 0.9663 | 0.9077 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7897.037 | 0.6187 | 0.0318 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7897.037 | 0.2977 | -0.6235 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7897.037 | 0.2977 | -0.6235 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7897.037 | 0.2832 | -0.6486 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7897.037 | 0.0824 | -0.9359 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7897.037 | 0.1609 | -0.8388 | 0.7255 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9664.037 | 1.0933 | 1.2373 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9664.037 | 1.0995 | 1.2535 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9664.037 | 1.0781 | 1.1983 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9664.037 | 1.0363 | 1.0917 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9664.037 | 0.3586 | -0.4493 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9664.037 | 0.3761 | -0.4152 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9664.037 | 0.2937 | -0.5715 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9664.037 | 0.1002 | -0.8892 | 0.7953 | |
| MDA-MB-415 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9664.037 | 0.0013 | -0.9995 | 0.7953 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7898.04 | 1.0574 | 1.1042 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7898.04 | 1.0333 | 1.0605 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7898.04 | 1.1186 | 1.2148 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7898.04 | 0.8829 | 0.7857 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7898.04 | 0.8131 | 0.6566 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7898.04 | 0.5571 | 0.1743 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7898.04 | 0.5937 | 0.2444 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7898.04 | 0.5311 | 0.1244 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7898.04 | 0.2207 | -0.4945 | 1.0987 |