Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10696.146 | 0.9544 | 0.8221 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10696.146 | 0.9264 | 0.7169 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10696.146 | 0.9802 | 0.9219 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10696.146 | 0.9623 | 0.8524 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10696.146 | 0.9115 | 0.6621 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10696.146 | 0.9338 | 0.7443 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10696.146 | 0.8207 | 0.3479 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11855.155 | 0.8992 | 0.7475 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11855.155 | 0.8911 | 0.7276 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11855.155 | 0.9045 | 0.7606 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11855.155 | 0.9008 | 0.7514 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11855.155 | 0.8057 | 0.5200 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11855.155 | 0.7166 | 0.3098 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11855.155 | 0.5403 | -0.0851 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11855.155 | 0.6922 | 0.2534 | 0.7873 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11855.155 | 0.5939 | 0.0319 | 0.7873 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12305.155 | 0.9408 | 0.9581 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12305.155 | 0.9346 | 0.9536 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12305.155 | 0.9781 | 0.9847 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12305.155 | 0.9386 | 0.9565 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12305.155 | 0.8122 | 0.8609 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12305.155 | 0.7390 | 0.8009 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12305.155 | 0.2697 | 0.2697 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12305.155 | 0.8702 | 0.9059 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12305.155 | 0.8450 | 0.8866 | 2.8841 |