Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12056.155 | 0.8779 | 0.7080 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12056.155 | 0.7841 | 0.4893 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12056.155 | 0.3735 | -0.3938 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12056.155 | 0.8044 | 0.5364 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12056.155 | 0.8338 | 0.6045 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12178.155 | 0.9314 | 0.8393 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12178.155 | 0.9534 | 0.8907 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12178.155 | 0.8806 | 0.7219 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12178.155 | 0.9499 | 0.8824 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12178.155 | 0.8650 | 0.6859 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12178.155 | 0.7066 | 0.3286 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12178.155 | 0.4634 | -0.1918 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12178.155 | 0.8713 | 0.7003 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12178.155 | 0.8178 | 0.5782 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12291.155 | 1.0739 | 1.3405 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12291.155 | 1.0162 | 1.0720 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12291.155 | 1.0366 | 1.1651 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12291.155 | 0.9864 | 0.9404 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12291.155 | 1.0010 | 1.0044 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12291.155 | 0.9642 | 0.8454 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12291.155 | 0.5513 | -0.4626 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12291.155 | 1.0114 | 1.0507 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12291.155 | 0.9685 | 0.8638 | 0.4532 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10696.146 | 1.0113 | 1.0454 | 0.5009 | |
| BT-483 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10696.146 | 0.9298 | 0.7297 | 0.5009 |