Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7919.043 | 1.0338 | 1.0211 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7919.043 | 1.0065 | 1.0041 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 7919.043 | 0.9671 | 0.9790 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 7919.043 | 0.6320 | 0.7308 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 7919.043 | 0.5604 | 0.6665 | 3.1744 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9844.034 | 1.0158 | 1.0141 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9844.034 | 1.1148 | 1.0998 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9844.034 | 0.8493 | 0.8589 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9844.034 | 1.0124 | 1.0111 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 9844.034 | 1.0310 | 1.0276 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 9844.034 | 1.0375 | 1.0333 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 9844.034 | 0.5476 | 0.5270 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 9844.034 | 0.1971 | -0.0339 | 2.2318 | |
| SUM159PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 9844.034 | 0.0467 | -0.4933 | 2.2318 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10146.121 | 1.0451 | 1.0880 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10146.121 | 1.1683 | 1.3278 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10146.121 | 1.0851 | 1.1659 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10146.121 | 1.1008 | 1.1965 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 10146.121 | 1.0842 | 1.1642 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 10146.121 | 0.9375 | 0.8780 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 10146.121 | 0.8216 | 0.6509 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 10146.121 | 0.7261 | 0.4634 | 1.0246 | |
| SUM185PE | TNBC | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10146.121 | 0.0959 | -0.7972 | 1.0246 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7536.078 | 1.1241 | 1.2107 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7536.078 | 1.0586 | 1.1000 | 1.1676 |