Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 9897.034 | 0.5573 | -0.5464 | 0.3940 | |
| T47D | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 9897.034 | 0.4151 | -0.7852 | 0.3940 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7926.077 | 1.0956 | 1.2369 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7926.077 | 1.1258 | 1.3124 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7926.077 | 1.0005 | 1.0013 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7926.077 | 1.0919 | 1.2274 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 7926.077 | 1.0271 | 1.0666 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 7926.077 | 1.0938 | 1.2324 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 7926.077 | 0.9508 | 0.8802 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 7926.077 | 0.7508 | 0.4077 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 7926.077 | 0.5258 | -0.0903 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10150.034 | 1.0736 | 1.4373 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10150.034 | 1.1523 | 1.9680 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10150.034 | 1.0459 | 1.2662 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10150.034 | 1.0770 | 1.4586 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 10150.034 | 1.0688 | 1.4073 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 10150.034 | 1.1219 | 1.7546 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 10150.034 | 0.7081 | -0.2349 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 10150.034 | 0.7405 | -0.1334 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 10150.034 | 0.6224 | -0.4657 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10151.034 | 1.1080 | 1.7486 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10151.034 | 1.1154 | 1.8060 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10151.034 | 1.0405 | 1.2621 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10151.034 | 1.0319 | 1.2042 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 10151.034 | 1.0971 | 1.6653 | 0.3226 |