Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7536.078 | 0.9460 | 0.9071 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7536.078 | 1.0966 | 1.1644 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.136 | uM | 7536.078 | 1.0340 | 1.0581 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.682 | uM | 7536.078 | 0.9860 | 0.9760 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 3.41 | uM | 7536.078 | 0.9107 | 0.8460 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 17.1 | uM | 7536.078 | 0.4130 | -0.0622 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 85.2 | uM | 7536.078 | 0.0511 | -0.8434 | 1.1676 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9860.121 | 0.9301 | 0.9190 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9860.121 | 1.0499 | 1.0562 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9860.121 | 0.9381 | 0.9285 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9860.121 | 1.0276 | 1.0312 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.136 | uM | 9860.121 | 1.0816 | 1.0915 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 0.682 | uM | 9860.121 | 0.9578 | 0.9515 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 3.41 | uM | 9860.121 | 0.7678 | 0.7204 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 17.1 | uM | 9860.121 | 0.3418 | 0.0848 | 1.7546 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 85.2 | uM | 9860.121 | 0.0436 | -0.6646 | 1.7546 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7538.078 | 0.9430 | 0.8699 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7538.078 | 1.1330 | 1.3073 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7538.078 | 0.8247 | 0.6041 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7538.078 | 0.9525 | 0.8915 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 7538.078 | 0.8567 | 0.6755 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 7538.078 | 0.8569 | 0.6758 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 7538.078 | 0.8995 | 0.7716 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 7538.078 | 0.8835 | 0.7355 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 7538.078 | 0.3908 | -0.3179 | 0.8734 |