Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9163.121 | 1.0468 | 1.2199 | 0.4382 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9163.121 | 1.0160 | 1.0738 | 0.4382 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9163.121 | 0.7764 | 0.1227 | 0.4382 | |
| BT-474 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9163.121 | 0.7893 | 0.1655 | 0.4382 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7801.007 | 0.9848 | 0.9531 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7801.007 | 0.9729 | 0.9166 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7801.007 | 0.9353 | 0.8030 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7801.007 | 0.9874 | 0.9610 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7801.007 | 0.9816 | 0.9432 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7801.007 | 0.9142 | 0.7402 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7801.007 | 0.9361 | 0.8053 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7801.007 | 0.7431 | 0.2619 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7801.007 | 0.5748 | -0.1528 | 0.6446 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9186.121 | 0.9779 | 0.9474 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9186.121 | 1.0435 | 1.1044 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9186.121 | 1.0452 | 1.1083 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9186.121 | 1.0355 | 1.0849 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9186.121 | 1.0336 | 1.0803 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9186.121 | 0.9690 | 0.9262 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9186.121 | 0.7893 | 0.5079 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9186.121 | 0.6956 | 0.2968 | 0.8379 | |
| BT-483 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9186.121 | 0.5526 | -0.0147 | 0.8379 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10261.121 | 0.9980 | 0.9982 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10261.121 | 1.0345 | 1.0303 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10261.121 | 0.9831 | 0.9849 | 2.2540 |