Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7875.017 | 0.9802 | 0.9753 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7875.017 | 1.0227 | 1.0281 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7875.017 | 0.8392 | 0.7938 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7875.017 | 0.7031 | 0.6072 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7875.017 | 0.1959 | -0.2731 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7875.017 | 0.0427 | -0.7177 | 1.6110 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9583.017 | 1.0572 | 1.1093 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9583.017 | 1.0103 | 1.0196 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9583.017 | 1.0717 | 1.1369 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9583.017 | 1.0091 | 1.0175 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9583.017 | 0.9723 | 0.9470 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9583.017 | 0.9381 | 0.8815 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9583.017 | 0.9002 | 0.8087 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9583.017 | 0.5367 | 0.1030 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9583.017 | 0.1994 | -0.5721 | 1.0456 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 10073.021 | 1.0374 | 1.1340 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 10073.021 | 1.0126 | 1.0448 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 10073.021 | 1.0061 | 1.0217 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 10073.021 | 1.0069 | 1.0245 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 10073.021 | 1.0246 | 1.0878 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 10073.021 | 0.9998 | 0.9993 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 10073.021 | 0.9790 | 0.9265 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 10073.021 | 0.6901 | 0.0391 | 0.5665 | |
| MCF7 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 10073.021 | 0.4272 | -0.5545 | 0.5665 | |
| MDA-MB-134-VI | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7876.017 | 1.1750 | 1.5438 | 0.6706 |