Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7813.018 | 0.6956 | 0.2995 | 0.8420 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7813.018 | 0.2481 | -0.6181 | 0.8420 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7813.018 | 0.0020 | -0.9987 | 0.8420 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.00128 | uM | 9254.124 | 1.0292 | 1.0726 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0064 | uM | 9254.124 | 1.0240 | 1.0598 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.032 | uM | 9254.124 | 1.0822 | 1.2057 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.16 | uM | 9254.124 | 0.8279 | 0.5825 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.8 | uM | 9254.124 | 0.7863 | 0.4846 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 4 | uM | 9254.124 | 0.8788 | 0.7040 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 20 | uM | 9254.124 | 0.9000 | 0.7551 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 100 | uM | 9254.124 | 0.7525 | 0.4057 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 500 | uM | 9254.124 | 0.6178 | 0.1010 | 0.8067 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9258.026 | 0.8437 | 0.4789 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9258.026 | 0.9807 | 0.9321 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9258.026 | 0.8571 | 0.5211 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9258.026 | 0.7383 | 0.1669 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9258.026 | 0.7057 | 0.0770 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 9258.026 | 0.7115 | 0.0927 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 9258.026 | 0.7582 | 0.2235 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 9258.026 | 0.5308 | -0.3505 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 9258.026 | 0.0020 | -1.0000 | 0.5632 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7818.018 | 0.9504 | 0.9002 | 0.9928 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7818.018 | 0.9109 | 0.8206 | 0.9928 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7818.018 | 0.9146 | 0.8279 | 0.9928 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7818.018 | 0.8321 | 0.6620 | 0.9928 |