Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7931.011 | 0.9133 | 0.8651 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7931.011 | 0.8167 | 0.7114 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7931.011 | 0.4087 | 0.0045 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7931.011 | 0.0291 | -0.8686 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7932.011 | 1.0292 | 1.0649 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7932.011 | 1.0693 | 1.1541 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7932.011 | 0.9599 | 0.9113 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7932.011 | 1.0158 | 1.0351 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7932.011 | 0.9903 | 0.9784 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7932.011 | 0.9754 | 0.9455 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7932.011 | 0.8463 | 0.6623 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7932.011 | 0.3842 | -0.3071 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7932.011 | 0.0312 | -0.9572 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9958.021 | 1.0239 | 1.0944 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9958.021 | 1.0030 | 1.0118 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9958.021 | 1.0325 | 1.1289 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9958.021 | 1.0207 | 1.0816 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.16 | uM | 9958.021 | 0.9743 | 0.9011 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9958.021 | 0.9153 | 0.6829 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9958.021 | 0.8453 | 0.4413 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9958.021 | 0.5442 | -0.3894 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9958.021 | 0.0651 | -0.9903 | 0.5129 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9972.011 | 1.2584 | 1.5520 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9972.011 | 1.2983 | 1.6378 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9972.011 | 1.2211 | 1.4717 | 0.9432 |