Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9972.011 | 1.2742 | 1.5859 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9972.011 | 1.2474 | 1.5283 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9972.011 | 1.1751 | 1.3731 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9972.011 | 0.9888 | 0.9762 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9972.011 | 0.7910 | 0.5598 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9972.011 | 0.1819 | -0.6718 | 0.9432 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9997.011 | 1.0878 | 1.1660 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9997.011 | 1.1752 | 1.3306 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9997.011 | 1.0794 | 1.1503 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9997.011 | 0.9952 | 0.9910 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9997.011 | 1.0681 | 1.1289 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9997.011 | 1.0543 | 1.1028 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9997.011 | 0.8755 | 0.7632 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9997.011 | 0.8652 | 0.7435 | 1.0551 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9997.011 | 0.2165 | -0.5311 | 1.0551 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 0.00427 | uM | 10581.136 | 0.9427 | 0.8635 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 0.0213 | uM | 10581.136 | 0.9355 | 0.8464 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 0.107 | uM | 10581.136 | 0.9808 | 0.9539 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 0.533 | uM | 10581.136 | 0.9521 | 0.8857 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 2.67 | uM | 10581.136 | 0.9142 | 0.7961 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 13.3 | uM | 10581.136 | 0.8735 | 0.7007 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 66.7 | uM | 10581.136 | 0.4525 | -0.2270 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 333 | uM | 10581.136 | 0.7751 | 0.4737 | 0.8342 | |
| BT-20 | TNBC | Basal A | Celecoxib | COX2 | COX | 1670 | uM | 10581.136 | 0.6351 | 0.1606 | 0.8342 | |
| CAMA-1 | HR+ | Luminal | Celecoxib | COX2 | COX | 0.00427 | uM | 10473.136 | 0.9625 | 0.9428 | 1.3186 |