Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9120.021 | 0.1479 | -0.8949 | 0.6486 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 7793.011 | 0.9798 | 0.9648 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 7793.011 | 0.9376 | 0.8906 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 7793.011 | 1.0211 | 1.0369 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 7793.011 | 0.9826 | 0.9696 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 7793.011 | 1.0007 | 1.0012 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 7793.011 | 0.7573 | 0.5690 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 7793.011 | 0.2986 | -0.3036 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 7793.011 | 0.0173 | -0.9420 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 7793.011 | 0.0054 | -0.9791 | 1.1456 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9146.12 | 0.9529 | 0.9153 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9146.12 | 1.1045 | 1.1868 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9146.12 | 0.9459 | 0.9026 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9146.12 | 1.0036 | 1.0065 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9146.12 | 0.9675 | 0.9414 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9146.12 | 0.6482 | 0.3550 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9146.12 | 0.2460 | -0.4325 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9146.12 | 0.0132 | -0.9589 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9146.12 | 0.0094 | -0.9696 | 1.1135 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9157.021 | 0.9771 | 0.9547 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9157.021 | 1.0010 | 1.0020 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9157.021 | 1.0075 | 1.0148 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9157.021 | 1.0043 | 1.0085 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.16 | uM | 9157.021 | 0.9787 | 0.9579 | 1.0111 | |
| BT-474 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9157.021 | 0.9902 | 0.9806 | 1.0111 |