Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13038.177 | 0.0099 | -0.9870 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13038.177 | 0.0112 | -0.9851 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13038.177 | 0.0002 | -0.9998 | 0.9161 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12702.177 | 1.0940 | 1.1175 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12702.177 | 1.0135 | 1.0171 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12702.177 | 0.9648 | 0.9549 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12702.177 | 1.0184 | 1.0234 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12702.177 | 0.9651 | 0.9554 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12702.177 | 0.0102 | -0.8916 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12702.177 | 0.0065 | -0.9190 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12702.177 | 0.0092 | -0.8984 | 1.5730 | |
| HCC1806 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12702.177 | 0.0067 | -0.9173 | 1.5730 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12617.177 | 0.9670 | 0.9605 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12617.177 | 0.9902 | 0.9883 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12617.177 | 0.9957 | 0.9948 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12617.177 | 0.9920 | 0.9905 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12617.177 | 0.9739 | 0.9688 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12617.177 | 0.0087 | -0.8812 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12617.177 | 0.0042 | -0.9223 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12617.177 | 0.0087 | -0.8812 | 1.6822 | |
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12617.177 | 0.0023 | -0.9458 | 1.6822 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12622.177 | 0.9881 | 0.9906 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12622.177 | 0.9971 | 0.9977 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12622.177 | 0.9970 | 0.9976 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12622.177 | 1.0003 | 1.0003 | 2.5433 |