Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12622.177 | 1.0059 | 1.0046 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12622.177 | 0.3140 | 0.2683 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12622.177 | 0.0063 | -0.7277 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12622.177 | 0.0102 | -0.6707 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12622.177 | 0.0042 | -0.7666 | 2.5433 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12627.177 | 0.9965 | 0.9946 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12627.177 | 0.9812 | 0.9708 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12627.177 | 1.0083 | 1.0129 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12627.177 | 1.0000 | 1.0000 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12627.177 | 0.9497 | 0.9217 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12627.177 | 0.6316 | 0.4010 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12627.177 | 0.0097 | -0.9449 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12627.177 | 0.0127 | -0.9321 | 1.2910 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12627.177 | 0.0069 | -0.9574 | 1.2910 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12944.177 | 1.1866 | 1.1743 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12944.177 | 1.1985 | 1.1849 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12944.177 | 1.1519 | 1.1430 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12944.177 | 1.0351 | 1.0340 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12944.177 | 0.0026 | -0.8903 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12944.177 | 0.0081 | -0.8101 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12944.177 | 0.0021 | -0.9023 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12944.177 | 0.0030 | -0.8822 | 2.0477 | |
| MCF 10A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12944.177 | 0.0004 | -0.9555 | 2.0477 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12949.177 | 1.0813 | 1.0902 | 1.7727 | |
| MCF12A | NM | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12949.177 | 0.9772 | 0.9741 | 1.7727 |