Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12647.177 | 0.0060 | -0.9856 | 1.0387 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13099.177 | 1.3106 | 1.8797 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13099.177 | 1.1941 | 1.5403 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13099.177 | 1.0516 | 1.1403 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13099.177 | 1.3495 | 1.9957 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13099.177 | 0.0209 | -0.9891 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13099.177 | 0.0025 | -0.9994 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13099.177 | 0.0017 | -0.9996 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13099.177 | 0.0032 | -0.9991 | 0.7419 | |
| HCC1143 | TNBC | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13099.177 | 0.0004 | -0.9999 | 0.7419 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12612.177 | 0.9313 | 0.7405 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12612.177 | 0.9361 | 0.7581 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12612.177 | 0.9615 | 0.8525 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12612.177 | 0.9317 | 0.7418 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12612.177 | 0.9142 | 0.6784 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12612.177 | 0.8939 | 0.6065 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12612.177 | 0.4616 | -0.5582 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12612.177 | 0.0123 | -0.9996 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12612.177 | 0.0092 | -0.9998 | 0.5119 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13038.177 | 1.2158 | 1.4755 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13038.177 | 0.9042 | 0.7918 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13038.177 | 1.2260 | 1.4981 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13038.177 | 1.2903 | 1.6415 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13038.177 | 0.2268 | -0.6041 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13038.177 | 0.0236 | -0.9666 | 0.9161 |