Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14221.189 | 0.9822 | 0.9770 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14221.189 | 0.9592 | 0.9471 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14221.189 | 0.9874 | 0.9838 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14221.189 | 0.9573 | 0.9447 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14221.189 | 1.0016 | 1.0020 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14221.189 | 0.8395 | 0.7870 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14221.189 | 0.0921 | -0.5690 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14221.189 | 0.0553 | -0.6896 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14221.189 | 0.0595 | -0.6746 | 1.5537 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14281.189 | 0.9650 | 0.8622 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14281.189 | 0.9514 | 0.8097 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14281.189 | 0.9958 | 0.9832 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14281.189 | 0.9546 | 0.8220 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14281.189 | 0.9758 | 0.9041 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14281.189 | 0.5400 | -0.4189 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14281.189 | 0.3792 | -0.7140 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 13.3 | uM | 14281.189 | 0.0110 | -0.9998 | 0.4986 | |
| SUM1315MO2 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 66.7 | uM | 14281.189 | 0.0095 | -0.9998 | 0.4986 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000171 | uM | 14284.189 | 0.9873 | 0.9816 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.000853 | uM | 14284.189 | 0.9497 | 0.9270 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.00427 | uM | 14284.189 | 0.9940 | 0.9913 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.0213 | uM | 14284.189 | 0.9978 | 0.9968 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.107 | uM | 14284.189 | 0.9812 | 0.9728 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 0.533 | uM | 14284.189 | 0.4919 | 0.1993 | 1.3873 | |
| SUM149PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 2.67 | uM | 14284.189 | 0.0526 | -0.7605 | 1.3873 |