Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7508.065 | 0.0155 | -0.9901 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7508.065 | 0.0174 | -0.9885 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7508.065 | 0.0139 | -0.9914 | 0.7854 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7510.065 | 1.1209 | 1.3637 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7510.065 | 1.0211 | 1.0621 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7510.065 | 0.9907 | 0.9727 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7510.065 | 0.9325 | 0.8054 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7510.065 | 0.8201 | 0.4960 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7510.065 | 0.5063 | -0.2616 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7510.065 | 0.3266 | -0.6114 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7510.065 | 0.1842 | -0.8320 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7510.065 | 0.1018 | -0.9294 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7511.065 | 0.9077 | 0.8476 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7511.065 | 0.9506 | 0.9187 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7511.065 | 0.9899 | 0.9834 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7511.065 | 0.9635 | 0.9400 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7511.065 | 0.9248 | 0.8760 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7511.065 | 0.5554 | 0.2358 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7511.065 | 0.4254 | -0.0065 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7511.065 | 0.2721 | -0.3108 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7511.065 | 0.2351 | -0.3886 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7512.065 | 0.9471 | 0.8849 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7512.065 | 1.0620 | 1.1354 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7512.065 | 0.9877 | 0.9731 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7512.065 | 1.0175 | 1.0382 | 0.9176 |