Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 10418.065 | 0.0204 | -0.9682 | 0.9401 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.048 | uM | 7470.065 | 0.9811 | 0.9628 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 0.24 | uM | 7470.065 | 1.0065 | 1.0128 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 1.2 | uM | 7470.065 | 0.9997 | 0.9994 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 6 | uM | 7470.065 | 0.9658 | 0.9325 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 30 | uM | 7470.065 | 0.7684 | 0.5419 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 150 | uM | 7470.065 | 0.2847 | -0.4216 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 750 | uM | 7470.065 | 0.0187 | -0.9607 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 3750 | uM | 7470.065 | 0.0132 | -0.9721 | 1.0127 | |
| HCC70 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 18700 | uM | 7470.065 | 0.0073 | -0.9845 | 1.0127 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7471.065 | 0.9129 | 0.9214 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7471.065 | 0.9582 | 0.9628 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7471.065 | 0.9971 | 0.9974 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7471.065 | 0.9779 | 0.9804 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7471.065 | 0.7975 | 0.8105 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7471.065 | 0.3344 | 0.2352 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7471.065 | 0.0355 | -0.5392 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7471.065 | 0.0093 | -0.7441 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7471.065 | 0.0075 | -0.7671 | 2.2733 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7472.065 | 0.8845 | 0.7653 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7472.065 | 1.3527 | 1.7195 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7472.065 | 0.9114 | 0.8199 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7472.065 | 1.1434 | 1.2920 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7472.065 | 1.2711 | 1.5527 | 0.9830 | |
| Hs 578T | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7472.065 | 2.1415 | 3.3396 | 0.9830 |