Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7512.065 | 0.9615 | 0.9161 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7512.065 | 0.6572 | 0.2659 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7512.065 | 0.4245 | -0.2138 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7512.065 | 0.2885 | -0.4840 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7512.065 | 0.1699 | -0.7101 | 0.9176 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7515.065 | 0.9569 | 0.9344 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7515.065 | 0.7107 | 0.5451 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7515.065 | 0.8979 | 0.8437 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7515.065 | 0.9999 | 0.9998 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7515.065 | 0.5131 | 0.2079 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7515.065 | 0.0401 | -0.8241 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7515.065 | 0.0184 | -0.9021 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7515.065 | 0.0251 | -0.8766 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7515.065 | 0.0145 | -0.9186 | 1.3234 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7516.065 | 0.9136 | 0.8680 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7516.065 | 0.9295 | 0.8924 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7516.065 | 0.9699 | 0.9543 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7516.065 | 0.9176 | 0.8740 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7516.065 | 0.6951 | 0.5191 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7516.065 | 0.0235 | -0.8826 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7516.065 | 0.0130 | -0.9253 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7516.065 | 0.0100 | -0.9388 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7516.065 | 0.0087 | -0.9445 | 1.3224 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7517.065 | 0.9637 | 0.9514 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7517.065 | 0.9267 | 0.9013 | 1.5040 |