Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7504.065 | 0.0524 | -0.6752 | 1.6220 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7506.065 | 0.8917 | 0.7928 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7506.065 | 1.0026 | 1.0049 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7506.065 | 0.9629 | 0.9291 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7506.065 | 0.9266 | 0.8596 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7506.065 | 0.9040 | 0.8163 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7506.065 | 0.3518 | -0.2623 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7506.065 | 0.0230 | -0.9455 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7506.065 | 0.0206 | -0.9509 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7506.065 | 0.0226 | -0.9462 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7507.065 | 0.9547 | 0.9107 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7507.065 | 0.9588 | 0.9187 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7507.065 | 0.9809 | 0.9623 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7507.065 | 0.9371 | 0.8759 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7507.065 | 0.8557 | 0.7153 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7507.065 | 0.4247 | -0.1398 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7507.065 | 0.0129 | -0.9725 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7507.065 | 0.0129 | -0.9726 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7507.065 | 0.0114 | -0.9756 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7508.065 | 1.0455 | 1.1166 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7508.065 | 1.0459 | 1.1176 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7508.065 | 0.9953 | 0.9880 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7508.065 | 0.9530 | 0.8811 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7508.065 | 0.8798 | 0.6991 | 0.7854 | |
| MDA-MB-361 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7508.065 | 0.3983 | -0.3806 | 0.7854 |