Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.96 | uM | 10694.143 | 0.9928 | 0.9935 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 4.8 | uM | 10694.143 | 0.9256 | 0.9317 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 24 | uM | 10694.143 | 0.9448 | 0.9496 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 120 | uM | 10694.143 | 0.9731 | 0.9757 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 600 | uM | 10694.143 | 0.9221 | 0.9284 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 3000 | uM | 10694.143 | 0.7366 | 0.7433 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 15000 | uM | 10694.143 | 0.2643 | 0.0999 | 2.2259 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10816.143 | 1.1665 | 1.7255 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10816.143 | 1.1963 | 1.8673 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10816.143 | 0.7689 | 0.1793 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10816.143 | 1.0319 | 1.1302 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10816.143 | 1.0803 | 1.3359 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10816.143 | 1.0498 | 1.2052 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10816.143 | 0.7582 | 0.1466 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10816.143 | 0.5330 | -0.4354 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10816.143 | 0.0098 | -0.9998 | 0.4975 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12319.143 | 0.8682 | 0.5221 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12319.143 | 0.7921 | 0.2751 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12319.143 | 1.2016 | 1.8517 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12319.143 | 0.9312 | 0.7427 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12319.143 | 0.9883 | 0.9550 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12319.143 | 0.9789 | 0.9192 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12319.143 | 1.0875 | 1.3515 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12319.143 | 0.2563 | -0.8557 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12319.143 | 0.0082 | -0.9998 | 0.5178 |